Surfactant-laden soft contact lenses for extended delivery of ophthalmic drugs

Y Kapoor, JC Thomas, G Tan, VT John, A Chauhan - Biomaterials, 2009 - Elsevier
Eye drops are inefficient means of delivering ophthalmic drugs because of limited bioavailability
and these can cause significant side effects due to systemic uptake of the drug. The …

[HTML][HTML] Interfacial stress in the development of biologics: fundamental understanding, current practice, and future perspective

…, D LaCasse, L Narhi, E Shalaev, IC Shieh, JC Thomas… - The AAPS journal, 2019 - Springer
Biologic products encounter various types of interfacial stress during development, manufacturing,
and clinical administration. When proteins come in contact with vapor–liquid, solid–…

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

JC Thomas, JM O'Hara, L Hu, FP Gao… - Human vaccines & …, 2013 - Taylor & Francis
There is great interest in the design and development of highly thermostable and immunogenic
protein subunit vaccines for biodefense. In this study, we used two orthogonal and …

Drug formulation impact on prefilled syringe functionality and autoinjector performance

…, CADÈ Richard, X Dong, JC Thomas… - PDA Journal of …, 2020 - journal.pda.org
Given the surging interest in developing prefilled syringe and autoinjector combination
products, investment in an early compatibility assessment is critical to prevent unwarranted drug/…

Novel ricin subunit antigens with enhanced capacity to elicit toxin-neutralizing antibody responses in mice

N Wahome, E Sully, C Singer, JC Thomas, L Hu… - Journal of …, 2016 - Elsevier
… The single point mutation precursors were computed by Justin C. Thomas, Jianwen Fang, …
Thomas acknowledges financial support from NIH T32 GM008359 and a pre-doctoral …

The physical analysis of vaccines

Y Cheng, JC Thomas, SB Joshi, DB Volkin… - Subunit Vaccine …, 2015 - Springer
The analysis of the structural integrity of biotechnology products and macromolecular systems
has become increasingly sophisticated. With regard to vaccines, the major problem has …

[HTML][HTML] The consequences of nuclear transfer for mammalian foetal development and offspring survival. A mitochondrial DNA perspective

JC St John, REI Lloyd, EJ Bowles, EC Thomas… - …, 2004 - rep.bioscientifica.com
The introduction of nuclear transfer (NT) and other technologies that involve embryo
reconstruction require us to reinvestigate patterns of mitochondrial DNA (mtDNA) transmission, …

[HTML][HTML] Synthesis and characterization of superparamagnetic iron-oxide nanoparticles (SPIONs) and utilization of SPIONs in X-ray imaging

C Justin, SA Philip, AV Samrot - Applied Nanoscience, 2017 - Springer
The versatility of superparamagnetic iron-oxide nanoparticles (SPIONs) have been
extensively investigated, especially for their applications in therapeutics and diagnostics. …

Limits to anatomical accuracy of diffusion tractography using modern approaches

…, Y Rathi, MO Irfanoglu, C Thomas, C Pierpaoli… - Neuroimage, 2019 - Elsevier
Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain,
with a range of applications in both clinical and basic neuroscience. Despite widespread …

Au/TiO2–gC3N4 Nanocomposites for Enhanced Photocatalytic H2 Production from Water under Visible Light Irradiation with Very Low Quantities of Sacrificial …

…, C Colbeau‐Justin… - Advanced Energy …, 2018 - Wiley Online Library
Here for the first time the design and optimization are presented of a three‐component Au/TiO
2 –gC 3 N 4 nanocomposite photocatalyst able to efficiently produce H 2 from water using …