Tumor necrosis factor alpha (TNF-alpha), also known as cachectin, was demonstrated to
induce the expression of human immunodeficiency virus (HIV) in a chronically infected T-cell …

Therapeutic protein products provide unique and effective treatments for numerous human
diseases and medical conditions. In many cases, these treatments are used chronically to …

AT cell clone (ACH-2) derived from T cells infected with HIV-1 was found to produce HIV-1
in response to stimulation with a monokine-enriched supernatant prepared by culturing …

The genome of the human immunodeficiency virus (HIV) contains several open reading frames
(ORFs) not present in other viruses. The 'A' gene 1 , also known as Q 2 P' 3 , ORF-1 4 or …

On February 22, 2013, the FDA licensed ado-trastuzumab emtansine (Kadcyla; Genentech,
Inc.) for use as a single agent for the treatment of patients with human epidermal growth …

The US Food and Drug Administration (FDA) describes the accelerated approval of brentuximab
vedotin for patients with relapsed Hodgkin lymphoma and relapsed systemic anaplastic …

Attachment of gp120 to CD4 during HIV-1 entry triggers structural rearrangement in gp120
that enables binding to an appropriate coreceptor. Following coreceptor engagement, …

✓ Despite years of research, delayed cerebral vasospasm remains a serious complication
of subarachnoid hemorrhage (SAH). Recently, it has been proposed that endothelin-1 (ET-1) …

Signal transduction through both cytokine and lymphocyte antigen receptors shares some
common pathways by which they initiate cellular responses, such as activation of mitogen-…

Results and conclusions concerning the ability of HIV glycoprotein (gp) 120 to stimulate
monokine secretion have been equivocal, based on observations using natural gp120 derived …