Disease-causing repeat instability is an important and unique form of mutation that is linked
to more than 40 neurological, neurodegenerative and neuromuscular disorders. DNA repeat …

Instability of the fragile X CGG repeat involves both maternally derived expansions and
deletions in the gametes of full-mutation males. It has also been suggested that the absence of …

Nucleosome packaging regulates many aspects of DNA metabolism and is thought to mediate
genetic instability and transcription of expanded trinucleotide repeats. Both instability and …

To compare the performances of conventional in vitro indicator cell culture, quantitative
polymerase chain reaction (qPCR), and next-generation sequencing (NGS) as detection …

Nucleosome packaging influences many aspects of DNA metabolism such as replication,
repair and transcription, and via this link likely has further downstream effects on genome …

In order to ensure the safety of vaccines produced on avian cells, rigorous testing for the
absence of avian retroviruses must be performed. Current methods used to detect avian …

Over the past few years, several recombinant ALVAC constructs have been used as delivery
systems in various vaccine research studies and trials. The ALVAC-HIV vCP1521 vector …

R-loops have been described at immunoglobulin class switch sequences, prokaryotic and
mitochondrial replication origins, and disease-associated (CAG)n and (GAA)n trinucleotide …

Expansions of (CTG)·(CAG) repeated DNAs are the mutagenic cause of 14 neurological
diseases, likely arising through the formation and processing of slipped-strand DNAs. These …

… Cleary, for adding levity to my graduate experience and for providing me with a superior
example of professionalism and scientific integrity; Kerrie Nichol Edamura, for critical …