OBJECTIVE: The pilot study examined the ability of octreotide to retard progression of diabetic
retinopathy (DR) and delay the need for panretinal photocoagulation (PRP) in patients …

The subacute and subchronic intravenous (iv) toxicity of 2-hydroxypropyl-β-cyclodextrin (HPCD)
was examined in Sprague-Dawley rats and cynomolgus monkeys. After either 14 or 90 …

The rapid antibiotic resistance development has created a major demand for new antimicrobial
agents that can combat resistant strains such as methicillin-resistant S. aureus (MRSA). …

A number of cyclodextrins were examined as to their ability to stabilize doxorubicin in solution
and to enhance the rate of its dissolution. 2-Hydroxypropyl-β-cyclodextrin (HPβCD), 2-…

A dihydropyridine ⇔ pyridinium salt chemical delivery system (CDS) for estradiol (E 2 CDS)
was complexed with various modified β‐cyclodextrins including hydroxyethyl‐β‐cyclodextrin …

The poor water solubility of alfaxalone (5 μg/mL). a useful steroid anesthetic agent, was
dramatically increased via complexation with a series of four cyclodextrins. The most effective …

The poor aqueous solubility of carbamazepine was dramatically increased via complexation
with various chemically modified β-cyclodextrins and γ-cyclodextrins. A preparation of …

Complexation of carbamazepine with 2-hydroxypropyl-β-cyclodextrin was performed to
provide improved formulations of this widely used antiepileptic drug. Based on this approach, …

We have recently demonstrated that drugs can be spe-cifically delivered to the central nervous
system (CNS) with use of a dihydropyridine^ pyridinium salt redox carrier system. 1 2" 3 …

Brain-targeted delivery systems based on the dihydropyridine<=* pyridinium salt redox
interconversion were synthesized for estradiol, estradiol 3-benzoate, and ethynylestradiol. Initial …