AP 5280 is a novel polymer-conjugated platinum anticancer agent currently in Phase I
clinical trials. In order to guarantee the quality of AP 5280 drug substance for use in the …

10.7554/eLife.36998.001 Forebrain precursor cells are dynamic during early brain development,
yet the underlying molecular changes remain elusive. We observed major differences …

Importance Refining eligibility guidelines may identify more appropriate patients to undergo
useful medical procedures. Objective To improve cost-effectiveness in selecting patients …

Massive, coordinated cellular changes accompany the transition of central nervous system (CNS)
progenitors from forebrain neurectodermal cells to specified neuroepithelial cells. We …

Background Conventional tunnel positions for single-bundle (SB) transtibial anterior cruciate
ligament (ACL) reconstruction are located in the posterolateral (PL) tibial footprint and the …

The Michigan Society of Thoracic and Cardiovascular Surgeons created a voluntary quality
collaborative with all the cardiac surgeons in the state and all hospitals doing adult cardiac …

Introduction Shoulder instability following traumatic glenohumeral dislocation is a common
injury sustained by athletes particularly in contact and collision sports. Overhead contact …

Background Mitotic rate is a strong, independent prognostic factor in patients with melanoma.
However, incorporating it into the melanoma staging system has proved challenging. …

Background Prior studies have implicated transfusion as a risk factor for mortality in coronary
artery bypass graft surgery (CABG). To further our understanding of the true association …

Choroid plexus tumors and ciliary body medulloepithelioma are predominantly pediatric
neoplasms. Progress in understanding the pathogenesis of these tumors has been hindered by …