Lactoferrin (LF) is an iron binding glycoprotein that is present in several mucosal secretions.
Many biological functions have been ascribed to LF. One of the functions of LF is the …

… Author links open overlay panel Klaas Poelstra a , Jai Prakash a b , Leonie Beljaars a …
Coupling of hyaluran to poly-l-lysine has shown to provide a successful option for gene delivery to …

Cytokines, growth factors, and other locally produced mediators play key roles in the regulation
of disease progression. During liver fibrosis, these mediators orchestrate the balance …

… preincubated in six-well culture plates (Costar, Cambridge, MA) in 3.2 mL WE supplemented
with 25 mmol/L glucose and 50 µg/mL gentamicin (Gibco) for 90 minutes at 37C, …

The key pathogenic event in liver fibrosis is the activation of hepatic stellate cells (HSC).
Consequently, new antifibrotic therapies are directed toward an inhibition of HSC activities. The …

… In the model of CCl4-induced liver fibrosis, rats were fed ad libitum with standard chow and
drinking water containing phenobarbital (0.3 g/L). Fibrosis was induced by inhalation of CCl4 …

In a search for natural proteins with anti-HIV activity, we screened a large set of purified proteins
from bovine milk and peptide fragments thereof. Because several charged proteins and …

Platelet derived growth factor (PDGF) is a key factor in the induction and progression of
fibrotic diseases with the activated fibroblast as its target cell. Drug targeting to the PDGF-…

Macrophages have been found to both promote liver fibrosis and contribute to its resolution
by acquiring different phenotypes based on signals from the micro-environment. The best-…

Liver fibrogenesis is a process tightly controlled by endogenous anti‐ and pro‐fibrogenic
factors. Interferon gamma (IFNγ) is a potent antifibrogenic cytokine in vitro and might therefore …