We provide an explicit asymptotic method to evaluate the performance of different response-adaptive
randomization procedures in clinical trials with continuous outcomes. We use this …

Few references deal with response-adaptive randomization procedures for survival outcomes
and those that do either dichotomize the outcomes or use a non-parametric approach. In …

Administration of biopharmaceutical products can generate immune response that may
severely impact the safety or efficacy of the products. Immunogenicity evaluation, required by …

The Bliss independence model is widely used to analyze drug combination data when
screening for candidate drug combinations. The method compares the observed combination …

Objective To assess the efficacy and safety of the anti–interleukin‐1α/β (anti– IL ‐1α/β) dual
variable domain immunoglobulin lutikizumab ( ABT ‐981) in patients with knee osteoarthritis …

This paper presents a new proof of a charaterization of fractional (g, f)-factors of a graph in
which multiple edges are allowed. From the proof a polynomial algorithm for finding the …

The toughness of a graph G, t(G), is defined as t(G)=min{|S|/ω(GS)|S⊆V(G),ω(GS)>1} where
ω(GS) denotes the number of components of GS or t(G)=+∞ if G is a complete graph. Much …

Background: Elevated fetal hemoglobin (HbF) is associated with improved outcomes in patients
with sickle cell disease (SCD). Exagamglogene autotemcel (exa-cel; formerly known as …

… topic by Zhang (2016). The chapters in Zhang discuss statistical methods for CMC as well
as drug discovery and nonclinical development. We believe our book complements Zhang by …

Biotherapeutic proteins induce undesired immune responses that can affect drug efficacy
and safety. For this reason, immunogenicity assessment is an integral part of drug …