Viral inactivation: low pH and detergent

L Durno, O Tounekti - PDA Journal of Pharmaceutical Science and …, 2015 - journal.pda.org
Laura Durno and Omar Tounekti …

Fast and highly selective determination of hemagglutinin content in quadrivalent influenza vaccine by reversed-phase high-performance liquid chromatography …

B Lorbetskie, N Fortin, L Durno, J Wang, C Li… - … of Chromatography A, 2017 - Elsevier
Seasonal inactivated quadrivalent influenza vaccines are currently formulated to include
antigens from two strains of influenza A and a strain from each of the two circulating influenza B …

Selective Capture and Determination of Receptor-Binding Hemagglutinin in Influenza Vaccine Preparations Using a Coupled Receptor-Binding/RP-HPLC Assay

…, AM Cunningham, M Lemieux, L Durno… - Analytical …, 2019 - ACS Publications
Influenza vaccine potency is determined by the quantification of immunologically active
hemagglutinin capable of eliciting neutralizing antibodies upon immunization. Currently, the …

Immunopathogenesis associated with formaldehyde-inactivated RSV vaccine in preclinical and clinical studies

A Muralidharan, C Li, L Wang, X Li - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Respiratory syncytial virus (RSV) infection is responsible for one-third of deaths
of acute lower respiratory infection in children less than one-year-old. The formaldehyde-…

EARLY COLECTOMY AND GENETIC PREDISPOSITION ARE ASSOCIATED WITH THE DEVELOPMENT OF DESMOID TUMORS IN FAMILIAL ADENOMATOUS …

CA Durno, T Berk, N Monga, Z Cohen… - Journal of Pediatric …, 2006 - journals.lww.com
Background: Desmoid tumors are rare, non-metastasising fibromatoses which can occur in
association with familial adenomatous polyposis (FAP). Desmoids have a prevalence of 10-…

[PDF][PDF] Functional repair assay for the diagnosis of constitutional mismatch repair deficiency from non-neoplastic tissue

…, YY Lee, M Zapotocky, E Bouffet, C Durno… - Journal of Clinical …, 2019 - drive.google.com
RESULTS All CMMRD cell lines had low MMR activity (n= 20; mean, 4.14 6 1.56%) relative
to controls (n= 6; mean, 44.00 6 8.65%; P,. 001). Repair was restored by complementation …

[HTML][HTML] Diverse Marinimicrobia bacteria may mediate coupled biogeochemical cycles along eco-thermodynamic gradients

AK Hawley, MK Nobu, JJ Wright, WE Durno… - Nature …, 2017 - nature.com
Microbial communities drive biogeochemical cycles through networks of metabolite exchange
that are structured along energetic gradients. As energy yields become limiting, these …

National Assessment of Title I. Final Report. Volume II: Closing the Reading Gap--Findings from a Randomized Trial of Four Reading Interventions for Striving …

…, W Mansfield, D Myers, F Stancavage, D Durno… - National Center for …, 2007 - ERIC
This two-volume report, and Summary of Key Findings, presents findings from the
congressionally mandated National Assessment of Title I on the implementation and impact of the …

[HTML][HTML] Methanotrophic community dynamics in a seasonally anoxic fjord: Saanich Inlet, British Columbia

…, DW Capelle, MP Bhatia, W Evan Durno… - Frontiers in Marine …, 2016 - frontiersin.org
Marine oxygen minimum zones (OMZs) play disproportionate roles in nutrient and climate
active trace gas cycling including nitrous oxide and methane, in the ocean. OMZs are currently …

Substitution mutational signatures in whole-genome–sequenced cancers in the UK population

A Degasperi, X Zou, T Dias Amarante… - Science, 2022 - science.org
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing
mutational signatures, imprints of DNA damage, and repair processes that have arisen …