To develop a rational approach for the formulation of lyophilized products, six bulking agents
commonly used in freeze-dried formulations were lyophilized under identical conditions, …

Purpose. To study the effect of change in the shape factor of real crystals on their dissolution
behavior using a potassium dichromate crystal as a model for particulates in general. …

Blending validation has become mandatory, partly through good manufacturing practice (GMP),
partly through a court action (the Barr decision) in 1993. Although feasibly carried out …

The impact of pepsin on the maintenance of supersaturated solution of the HCl salt of a weakly
basic drug was evaluated in simulated gastric fluid by monitoring the drug solubility in the …

It has been demonstrated theoretically that the particle size distribution of particles in a
given sieve fraction of a powder may be assessed by means of short-term dissolution data. …

The objective is to provide mechanistic understanding of a preferred wet granulation process
that a binder is added in a dry state. Blends of CaCO 3 and binders were prepared and …

Synthesis of phosphonooxymethyl derivatives of ravuconazole, 2 (BMS-379224) and 3 (BMS-315801)
and their biological evaluation as potential water-soluble prodrugs of …

… Mandar Dali … Baird, Liangxian Cao, Mandar Dali, Bansri Furia, Min Jung Kim, Kylie O'Keefe,
Ronald Kong, Oscar L. Laskin, Joseph M. Colacino, Mark Pykett, Anna Mollin, Josephine …

Drug-excipient compatibility studies lay the foundation for designing a chemically stable
formulation for clinical and commercial development. This article describes the investigation of …

PTC299 is a novel small molecule that specifically blocks the production of protein from
selected mRNAs that under certain conditions use noncanonical ribosomal translational …