User profiles for Marc Pelletier
 | Marc PelletierCase Western Reserve University Verified email at uhhospitals.org Cited by 5431 |
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
…, P Daublain, L Zhang, BA Lutterbach, MR Pelletier… - Cancer discovery, 2013 - AACR
The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale
for targeting the mitogen-activated protein kinase (MAPK) pathway. Selective BRAF and …
for targeting the mitogen-activated protein kinase (MAPK) pathway. Selective BRAF and …
Anatomical and procedural features associated with aortic root rupture during balloon-expandable transcatheter aortic valve replacement
…, J Min, G Feuchtner, R Gurtvich, F Alqoofi, M Pelletier… - Circulation, 2013 - Am Heart Assoc
Background— Aortic root rupture is a major concern with balloon-expandable transcatheter
aortic valve replacement (TAVR). We sought to identify predictors of aortic root rupture …
aortic valve replacement (TAVR). We sought to identify predictors of aortic root rupture …
Phase I dose-escalation trial of MIW815 (ADU-S100), an intratumoral STING agonist, in patients with advanced/metastatic solid tumors or lymphomas
…, M Ingham, N Lewis, X Chen, M Pelletier… - Clinical Cancer …, 2022 - AACR
Purpose: This phase I study assessed the safety, pharmacokinetics (PKs), and efficacy of
MIW815 (ADU-S100), a novel synthetic cyclic dinucleotide that activates the stimulator of IFN …
MIW815 (ADU-S100), a novel synthetic cyclic dinucleotide that activates the stimulator of IFN …
Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency
J Li, MR Pelletier, JLP Velazquez, PL Carlen - Molecular and Cellular …, 2002 - Elsevier
Lack of expression of the fragile X mental retardation protein (FMRP), due to silencing of the
FMR1 gene, causes the Fragile X syndrome. Although FMRP was characterized previously …
FMR1 gene, causes the Fragile X syndrome. Although FMRP was characterized previously …
Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG
R Musa-Aziz, LM Chen, MF Pelletier… - Proceedings of the …, 2009 - National Acad Sciences
The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO
2 and NH 3 . Here, we use changes in surface pH (pH S ) to assess relative CO 2 vs. NH 3 …
2 and NH 3 . Here, we use changes in surface pH (pH S ) to assess relative CO 2 vs. NH 3 …
Aspirin versus aspirin plus clopidogrel as antithrombotic treatment following transcatheter aortic valve replacement with a balloon-expandable valve: the ARTE …
…, RC Welsh, B Garcia del Blanco, M Pelletier… - JACC: Cardiovascular …, 2017 - jacc.org
Objectives : The aim of this study was to compare aspirin plus clopidogrel with aspirin alone
as antithrombotic treatment following transcatheter aortic valve replacement (TAVR) for the …
as antithrombotic treatment following transcatheter aortic valve replacement (TAVR) for the …
[HTML][HTML] TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
…, J Chang, J Chen, M Piquet, M Pelletier… - Nature …, 2020 - nature.com
Despite the increasing interest in targeting stromal elements of the tumor microenvironment,
we still face tremendous challenges in developing adequate therapeutics to modify the …
we still face tremendous challenges in developing adequate therapeutics to modify the …
In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure
…, DT Huynh, AJ Connolly, MP Pelletier… - American Journal …, 2008 - journals.physiology.org
Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has
a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …
a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …
Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA
…, TG Cachero, F Qian, Y Sun, D Wen, M Pelletier… - Biochemistry, 2005 - ACS Publications
BAFF (B cell activating factor of the TNF family, also known as BlyS and TALL-1), a TNF family
cytokine critical for the development and function of B cells, has been reported to bind to …
cytokine critical for the development and function of B cells, has been reported to bind to …
Transcatheter mitral valve replacement after surgical repair or replacement: comprehensive midterm evaluation of valve-in-valve and valve-in-ring implantation from …
…, M Napodano, P Codner, J Schofer, M Pelletier… - Circulation, 2021 - Am Heart Assoc
Background: Mitral valve-in-valve (ViV) and valve-in-ring (ViR) are alternatives to surgical
reoperation in patients with recurrent mitral valve failure after previous surgical valve repair or …
reoperation in patients with recurrent mitral valve failure after previous surgical valve repair or …