Cell‐free synthesis and maturation of [FeFe] hydrogenases

ME Boyer, JA Stapleton… - Biotechnology and …, 2008 - Wiley Online Library
[FeFe] hydrogenases catalyze the reversible reduction of protons to molecular hydrogen (Adams
(1990); Biochim Biophys Acta 1020 (2): 115–145) and are of significant interest for the …

Cell culture process operations for recombinant protein production

S Abu-Absi, S Xu, H Graham, N Dalal, M Boyer… - Mammalian cell cultures …, 2014 - Springer
<?xm-replace_text {Heading}?> Abstract The market for protein therapeutics has grown
significantly over the past two decades and the pace of development continues to increase. It is …

Simultaneous expression and maturation of the iron‐sulfur protein ferredoxin in a cell‐free system

ME Boyer, CW Wang, JR Swartz - Biotechnology and …, 2006 - Wiley Online Library
The model iron‐sulfur (Fe‐S) protein ferredoxin (Fd) from Synechocystis sp. PCC 6803 has
been simultaneously produced and matured in a cell‐free production system. After 6 h of …

A roadmap for the implementation of continued process verification

M Boyer, J Gampfer, A Zamamiri… - PDA Journal of …, 2016 - journal.pda.org
In 2014, the members of the BioPhorum Operations Group (BPOG) produced a 100-page
continued process verification case study, entitled “Continued Process Verification: An Industry …

The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

…, J Seleski, GE Korzeniewski, K Erickson, Y Marcus… - Science, 2015 - science.org
Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

[HTML][HTML] The genotype-tissue expression (GTEx) project

…, M Donovan, Y Meng, G Grant, D Mash, Y Marcus… - Nature …, 2013 - nature.com
Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE

QD Nguyen, DM Brown, DM Marcus, DS Boyer, S Patel… - Ophthalmology, 2012 - Elsevier
PURPOSE: To evaluate the efficacy and safety of intravitreal ranibizumab in diabetic
macular edema (DME) patients. DESIGN: Two parallel, methodologically identical, phase III, …

[HTML][HTML] Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE

DM Brown, QD Nguyen, DM Marcus, DS Boyer, S Patel… - Ophthalmology, 2013 - Elsevier
Boyer MD 4 , Sunil Patel MD, PhD 5 , Leonard Feiner MD, PhD 6 , Patricio G. Schlottmann
MD 7 , Amy Chen Rundle MS 8 , Jiameng Zhang PhD 8 , Roman G. Rubio MD 8 , Anthony P. …

Intravitreal aflibercept for diabetic macular edema

…, E Midena, PK Kaiser, H Terasaki, DM Marcus… - Ophthalmology, 2014 - Elsevier
Purpose A head-to-head comparison was performed between vascular endothelial growth
factor blockade and laser for treatment of diabetic macular edema (DME). Design Two …

Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies

…, JS Heier, H Terasaki, PK Kaiser, DM Marcus… - Ophthalmology, 2015 - Elsevier
Boyer MD 5 , Edoardo Midena MD 6 , Jeffrey S. Heier MD 7 , Hiroko Terasaki MD 8 , Peter
K. Kaiser MD 9 , … Marcus MD 10 , Quan D. Nguyen MD 3 , Glenn J. Jaffe MD 11 , Jason S. …