Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization
T Loftsson, ME Brewster - Journal of pharmaceutical sciences, 1996 - Wiley Online Library
Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful
pharmaceutical excipients. The molecular structure of these glucose derivatives, which …
pharmaceutical excipients. The molecular structure of these glucose derivatives, which …
Cyclodextrin-based pharmaceutics: past, present and future
ME Davis, ME Brewster - Nature reviews Drug discovery, 2004 - nature.com
Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes
with small molecules and portions of large compounds. These biocompatible, cyclic …
with small molecules and portions of large compounds. These biocompatible, cyclic …
Cyclodextrins as pharmaceutical solubilizers
ME Brewster, T Loftsson - Advanced drug delivery reviews, 2007 - Elsevier
Cyclodextrins are useful functional excipients that have enjoyed widespread attention and
use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these …
use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these …
Pharmaceutical applications of cyclodextrins: basic science and product development
T Loftsson, ME Brewster - Journal of pharmacy and …, 2010 - academic.oup.com
Objectives Drug pipelines are becoming increasingly difficult to formulate. This is punctuated
by both retrospective and prospective analyses that show that while 40% of currently …
by both retrospective and prospective analyses that show that while 40% of currently …
Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?
J Brouwers, ME Brewster, P Augustijns - Journal of pharmaceutical …, 2009 - Elsevier
: Contemporary pharmaceutical pipelines are often highly populated with poorly water-soluble
drug candidates necessitating novel formulation technologies to provide dosage forms …
drug candidates necessitating novel formulation technologies to provide dosage forms …
Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer
…, A Van Dijck, J Mensch, M Noppe, ME Brewster - Journal of controlled …, 2003 - Elsevier
Electrostatic spinning was applied to the preparation of drug-laden nonbiodegradable
nanofiber for potential use in topical drug administration and wound healing. The specific aim of …
nanofiber for potential use in topical drug administration and wound healing. The specific aim of …
Self-association of cyclodextrins and cyclodextrin complexes
T Loftsson, M Másson, ME Brewster - Journal of pharmaceutical sciences, 2004 - Elsevier
Cyclodextrins are useful functional excipients, which are being used in an ever-increasing
way to camouflage undesirable pharmaceutical characteristics, especially poor aqueous …
way to camouflage undesirable pharmaceutical characteristics, especially poor aqueous …
Cyclodextrins as functional excipients: methods to enhance complexation efficiency
T Loftsson, ME Brewster - Journal of pharmaceutical sciences, 2012 - Elsevier
Cyclodextrins have gained currency as useful solubilizing excipients with an ever increasing
list of beneficial properties and functionalities. Although their use in liquid dosage forms …
list of beneficial properties and functionalities. Although their use in liquid dosage forms …
Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning
…, I Chun, J Peeters, J Rosenblatt, ME Brewster - Pharmaceutical …, 2003 - Springer
Purpose. We assessed the application of water-soluble polymer-based nanofibers prepared
by electrostatic spinning as a means of altering the dissolution rate of the poorly water-…
by electrostatic spinning as a means of altering the dissolution rate of the poorly water-…
Role of cyclodextrins in improving oral drug delivery
T Loftsson, ME Brewster, M Masson - American Journal of Drug Delivery, 2004 - Springer
The use of high-throughput screening and similar techniques in drug discovery has put a
number of evolutionary pressures on drug candidates such that over time there is a tendency …
number of evolutionary pressures on drug candidates such that over time there is a tendency …