Remodeling of the extracellular matrix (ECM), which occurs during many physiological and
pathological processes, is one of the requisite events of cellular invasion. The matrix …

The tissue inhibitors of metalloproteinases (TIMPs) block matrix metalloproteinase (MMP)-mediated
increases in cell proliferation, migration, and invasion that are associated with …

This study reports on the direct effect of the envelope glycoprotein (gp120) of the human
immunodeficiency virus type 1 (HIV-1) on human monocyte function. Addition of preparations of …

In addition to inhibiting the proteolytic activity of the matrix metalloproteinases, tissue
inhibitors of metalloproteinases (TIMPs) promote the growth of cells in the absence of other …

Matrix metalloproteinases (MMPs) function in the remodeling of the extracellular matrix that
is integral for many normal and pathological processes. The tissue inhibitor of …

Tissue inhibitor of metalloproteinases (TIMP-2) is a low molecular weight proteinase inhibitor
capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP-2 is found both free …

The laminin-derived synthetic peptide containing the SIKVAV (Ser-Ile-Lys-Val-Ala-Val) amino
acid sequence has been previously shown to regulate tumor invasion, metastasis, and …

Activation of human monocytes induces the production of matrix metalloproteinases (MMPs)
through a prostaglandin E 2 (PGE 2 )-cAMP-dependent pathway. Since G-proteins have …

Angiogenesis has been investigated in vivo using subcutaneously injected reconstituted
basement membrane (Matrigel) supplemented with angiogenic factors. Previously we found …

The effective management of leachables in pharmaceutical products is a critical aspect of
their development. This can be facilitated if extractables information on the materials used in a …