User profiles for Martin Hegner

Martin Hegner

School of Physics, Trinity College Dublin
Verified email at tcd.ie
Cited by 9849

Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array

…, J Zhang, Y Arntz, T Strunz, M Hegner… - Proceedings of the …, 2002 - National Acad Sciences
We report a microarray of cantilevers to detect multiple unlabeled biomolecules simultaneously
at nanomolar concentrations within minutes. Ligand-receptor binding interactions such …

Ultralarge atomically flat template-stripped Au surfaces for scanning probe microscopy

M Hegner, P Wagner, G Semenza - Surface Science, 1993 - Elsevier
We have devised a method to produce gold films with ultralarge atomically flat areas for use
in scanning probe microscopy. A means roughness of 2 Å for areas of 2.25 μm 2 , and about …

Specific antigen/antibody interactions measured by force microscopy

U Dammer, M Hegner, D Anselmetti, P Wagner… - Biophysical journal, 1996 - cell.com
Molecular recognition between biotinylated bovine serum albumin and polyclonal, biotin-directed
IG antibodies has been measured directly under various buffer conditions using an …

Formation and in situ modification of monolayers chemisorbed on ultraflat template-stripped gold surfaces

P Wagner, M Hegner, HJ Guentherodt, G Semenza - Langmuir, 1995 - ACS Publications
All of them are based on the same principle, ie, that of exposing the very first layer of gold
atoms which had deposited onto mica. One alternative route leads to substrates which are …

Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA

…, R McKendry, HJ Güntherodt, M Hegner… - Nature …, 2006 - nature.com
The availability of entire genome sequences has triggered the development of microarrays
for clinical diagnostics that measure the expression levels of specific genes. Methods that …

A label-free immunosensor array using single-chain antibody fragments

…, HP Lang, HJ Güntherodt, M Hegner… - Proceedings of the …, 2005 - National Acad Sciences
We report a microcantilever-based immunosensor operated in static deflection mode with a
performance comparable with surface plasmon resonance, using single-chain Fv (scFv) …

[HTML][HTML] Cantilever array sensors

HP Lang, M Hegner, C Gerber - Materials today, 2005 - Elsevier
Miniaturized microfabricated sensors have enormous potential in gas detection, biochemical
analysis, medical applications, quality and process control, and product authenticity issues. …

Rapid functionalization of cantilever array sensors by inkjet printing

A Bietsch, J Zhang, M Hegner, HP Lang… - Nanotechnology, 2004 - iopscience.iop.org
The controlled deposition of functional layers is the key to converting nanomechanical cantilevers
into chemical or biochemical sensors. Here, we introduce inkjet printing as a rapid and …

Quantitative time-resolved measurement of membrane protein–ligand interactions using microcantilever array sensors

…, HP Lang, A Bietsch, C Gerber, M Hegner - Nature …, 2009 - nature.com
Membrane proteins are central to many biological processes, and the interactions between
transmembrane protein receptors and their ligands are of fundamental importance in medical …

Polymerization and mechanical properties of single RecA–DNA filaments

M Hegner, SB Smith… - Proceedings of the …, 1999 - National Acad Sciences
The polymerization of individual RecA–DNA filaments, containing either single-stranded or
double-stranded DNA, was followed in real time, and their mechanical properties were …