User profiles for Matthew D. Bruss
Matthew D. BrussVerona Area High School Verified email at verona.k12.wi.us Cited by 2241 |
Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity
In 3T3-L1 adipocytes, insulin-stimulated GLUT4 translocation requires phosphorylation of
the protein designated Akt substrate of 160 kDa (AS160). Both insulin and contractions …
the protein designated Akt substrate of 160 kDa (AS160). Both insulin and contractions …
Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
MD Bruss, CF Khambatta, MA Ruby… - American Journal …, 2010 - journals.physiology.org
Calorie restriction (CR) increases longevity and retards the development of many chronic
diseases, but the underlying metabolic signals are poorly understood. Increased fatty acid (FA) …
diseases, but the underlying metabolic signals are poorly understood. Increased fatty acid (FA) …
Signaling from β1‐ and β2‐adrenergic receptors is defined by differential interactions with PDE4
W Richter, P Day, R Agrawal, MD Bruss… - The EMBO …, 2008 - embopress.org
β 1 ‐ and β 2 ‐adrenergic receptors (βARs) are highly homologous, yet they play clearly
distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily …
distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily …
A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction
It is proposed that caloric restriction (CR) increases mitochondrial biogenesis. However, it is
not clear why CR increases an energetically costly biosynthetic process. We hypothesized …
not clear why CR increases an energetically costly biosynthetic process. We hypothesized …
[HTML][HTML] The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics
Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining
this effect suggests that protein degradation, including mitochondrial autophagy, is increased …
this effect suggests that protein degradation, including mitochondrial autophagy, is increased …
[HTML][HTML] Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets
Complex diseases result from molecular changes induced by multiple genetic factors and
the environment. To derive a systems view of how genetic loci interact in the context of tissue-…
the environment. To derive a systems view of how genetic loci interact in the context of tissue-…
Calorie restriction does not increase short-term or long-term protein synthesis
Increased protein synthesis is proposed as a mechanism of life-span extension during
caloric restriction (CR). We hypothesized that CR does not increase protein synthesis in all …
caloric restriction (CR). We hypothesized that CR does not increase protein synthesis in all …
Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells
RD Learish, MD Bruss, M Haak-Frendscho - Developmental Brain …, 2000 - Elsevier
Nestin-expressing neural progenitor (NP) cells have been isolated from the subventricular
zone (SVZ) of the brain and propagated with epidermal growth factor (EGF) and basic …
zone (SVZ) of the brain and propagated with epidermal growth factor (EGF) and basic …
Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice
Combating the social and economic consequences of a growing elderly population will
require the identification of interventions that slow the development of age‐related diseases. …
require the identification of interventions that slow the development of age‐related diseases. …
[HTML][HTML] Critical role of PDE4D in β2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts
One of the defining properties of β 2 -adrenergic receptor (β 2 AR) signaling is the transient
and rapidly reversed accumulation of cAMP. Here we have investigated the contribution of …
and rapidly reversed accumulation of cAMP. Here we have investigated the contribution of …