In 3T3-L1 adipocytes, insulin-stimulated GLUT4 translocation requires phosphorylation of
the protein designated Akt substrate of 160 kDa (AS160). Both insulin and contractions …

Calorie restriction (CR) increases longevity and retards the development of many chronic
diseases, but the underlying metabolic signals are poorly understood. Increased fatty acid (FA) …

β 1 ‐ and β 2 ‐adrenergic receptors (βARs) are highly homologous, yet they play clearly
distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily …

It is proposed that caloric restriction (CR) increases mitochondrial biogenesis. However, it is
not clear why CR increases an energetically costly biosynthetic process. We hypothesized …

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining
this effect suggests that protein degradation, including mitochondrial autophagy, is increased …

Complex diseases result from molecular changes induced by multiple genetic factors and
the environment. To derive a systems view of how genetic loci interact in the context of tissue-…

Increased protein synthesis is proposed as a mechanism of life-span extension during
caloric restriction (CR). We hypothesized that CR does not increase protein synthesis in all …

Nestin-expressing neural progenitor (NP) cells have been isolated from the subventricular
zone (SVZ) of the brain and propagated with epidermal growth factor (EGF) and basic …

Combating the social and economic consequences of a growing elderly population will
require the identification of interventions that slow the development of age‐related diseases. …

One of the defining properties of β 2 -adrenergic receptor (β 2 AR) signaling is the transient
and rapidly reversed accumulation of cAMP. Here we have investigated the contribution of …