Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency
…, G Rechavi, V Magimairajan, MF Walsh… - Journal of clinical …, 2016 - ascopubs.org
Purpose Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic
mismatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome …
mismatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome …
[HTML][HTML] Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis
…, P van Paassen, D Walsh, M Walsh… - … England Journal of …, 2010 - Mass Medical Soc
Background Cyclophosphamide induction regimens for antineutrophil cytoplasmic antibody
(ANCA)–associated vasculitis are effective in 70 to 90% of patients, but they are associated …
(ANCA)–associated vasculitis are effective in 70 to 90% of patients, but they are associated …
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
…, D Broadhurst, N Zhang, A Hayes, MC Walsh… - Nature …, 2001 - nature.com
A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae,
and of those sequenced in other organisms, encode proteins of unknown function. Many of …
and of those sequenced in other organisms, encode proteins of unknown function. Many of …
[HTML][HTML] Inherited DNA-repair gene mutations in men with metastatic prostate cancer
Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …
[HTML][HTML] Germline mutations in predisposition genes in pediatric cancer
Background The prevalence and spectrum of predisposing mutations among children and
adolescents with cancer are largely unknown. Knowledge of such mutations may improve the …
adolescents with cancer are largely unknown. Knowledge of such mutations may improve the …
Using Fourier transform IR spectroscopy to analyze biological materials
…, GD Sockalingum, J Sulé-Suso, RJ Strong, MJ Walsh… - Nature protocols, 2014 - nature.com
IR spectroscopy is an excellent method for biological analyses. It enables the nonperturbative,
label-free extraction of biochemical information and images toward diagnosis and the …
label-free extraction of biochemical information and images toward diagnosis and the …
Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network …
…, R Rodriguez-Gutierrez, M Walsh… - Bmj, 2021 - bmj.com
Objective To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like
peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying …
peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying …
Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension
Background: Intraoperative hypotension may contribute to postoperative acute kidney injury
(AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors …
(AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors …
The genomic landscape of hypodiploid acute lymphoblastic leukemia
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …
Using Raman spectroscopy to characterize biological materials
Raman spectroscopy can be used to measure the chemical composition of a sample, which
can in turn be used to extract biological information. Many materials have characteristic …
can in turn be used to extract biological information. Many materials have characteristic …