The quaternary salt berberine can be delivered to the brain by injecting the lipoidal
dihydroberberine, which is converted in vivo to berberine. The efflux from the brain of the berberine …

… Effect of betaxoxime (BO) on the IOP of 4 ocular hypertensive patients in a phase 1/2
single-center, open-label, single group study shown as change in IOP versus baseline. Statistically …

… Loftsson T, Bodor N. The pharmacokinetics and transdermal delivery of loteprednol … A
randomized, double-masked, placebo-controlled parallel study of 0.2% loteprednol etabonate in …

… Nicholas Bodor … Bodor, who advocated the design ofpredictably andsafely metabolizable
drugs, … support andlove of our families: Sheryl, Nicole, andErik Bodor and Amy,Zoltan, …

… This difference may be due to the much higher lipophilicity of the BO. … and Bodor, N. Oxidation
of aryloxyaminoalcohols with activated dimethyl sulfoxide; a novel cn oxidation facilitated …

Chemical reactivity and other characteristics of α-d-glucopyranose and β-maltose were
evaluated within a semiempirical molecular orbital (AM1) framework. Theoretically generated …

… Bodor. Design, pharmacokinetic, and pharmacodynamic evaluation of soft anticholinergics
based on tropyl alpha-phenylcyclopeneacetate. Pharmazie 57:115–121 (2002). …

We have recently demonstrated that drugs can be spe-cifically delivered to the central nervous
system (CNS) with use of a dihydropyridine^ pyridinium salt redox carrier system. 1 2" 3 …

Publisher Summary A site-specific delivery designed for the central nervous system (CNS)
is useful. It is known that many of the pharmacologically active and important agents, …

Many drugs can be selectively delivered to the brain by using a dihydropyridine ⥂
pyridinium salt chemical delivery system (CDS). The interaction of these systems with central …