Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate
the role of histamine, we generated HDC‐deficient mice using a gene targeting method. …

We examined the in vivo role of membrane-bound prostaglandin E synthase (mPGES)-1, a
terminal enzyme in the PGE 2 -biosynthetic pathway, using mPGES-1 knockout (KO) mice. …

Histamine plays important roles in inflammation and nervous irritability in allergic disorders,
including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic …

This study revealed that the absence of histamine in histidine decarboxylase gene-knockout
(HDC −/− ) mice resulted in delayed cutaneous wound healing and that exogenously …

Histamine is a well-known mediator of inflammation that is released from mast cells and
basophils. To date, many studies using histamine receptor antagonists have shown that …

Oligodeoxynucleotides containing CpG motifs have been highlighted as potent Th1 activators.
We previously reported that Ag and CpG, when conjugated together, synergistically …

We have analyzed the role of histamine in the angiogenesis of the granulation tissue in
histidine decarboxylase–deficient (HDC−/−) mice, mast cell–deficient mice (WBB6F1-W/WV), …

The extract of the root of Acanthopanax chiisanensis Nakai is used for the treatment of
inflammation. To analyse the action mechanism of this extract, the effect of hyperin (quercetin‐3‐O…

The role of mitogen-activated protein (MAP) kinase in the release of arachidonic acid was
examined in a mutated mast cell (RBL-2H3(m1)) line that expressed both native Fc epsilon R1 …

Genetic polymorphisms of enzymes involved in the metabolism of carcinogens are suggested
to modify an individual’s susceptibility to lung cancer. The purpose of this study was to …