Water-soluble isoindoloquinoxalin (IIQ) imines and the corresponding acetates were
conveniently prepared from the key intermediates 2-(2′-aminophenyl)-2H-isoindole-1-…

The mechanism of action of clinically used Pt-based drugs is through the formation of stable
DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or …

α-Lactalbumin (LA) forms with oleic acid (OA) a complex which has been reported to induce
the selective death of tumor cells. However, the mechanism by which this complex kills a …

The quinoline motif fused with other heterocyclic systems plays an important role in the field
of anticancer drug development. An extensive series of tetracyclic quinolino[3,4-b]…

AS-48 is a 70-residue circular peptide from Enterococcus faecalis with a broad antibacterial
activity. Here, we produced by limited proteolysis a protein species carrying a single nicking …

Recent findings have unambiguously demonstrated that DNA G-rich sequences can adopt
a G-quadruplex folding in living cells, thus further validating them as crucial targets for …

It is well known that G‐quadruplexes are targets of great interest for their roles in crucial
biological processes, such as aging and cancer. Hence, a promising strategy for anticancer drug …

Although wild-type hen egg white lysozyme (HEL) is lacking the consensus sequence motif
NX(S/T), in 1995 Trudel et al. (Biochem. Cell Biol. 1995, 73, 307–309) proposed the …

The use of glass for pharmaceutical new applications such as high-technology drugs,
requires the strictest container inertness. A common theme of paramount importance in glass …

Abstract Development of novel pharmaceutical drug modalities has created a need for frozen
storage and transportation. Accurate and easy assessment of container closure integrity (…