We have investigated the use of column chromatography for the purification of ACN53, a
recombinant adenovirus type 5 encoding the human p53 tumor suppressor protein. Anion …

Mutated in multiple advanced cancers 1/phosphatase and tensin homologue (MMAC1/PTEN)
is a novel tumor suppressor gene candidate located on chromosome 10 that is commonly …

The expanding use of adenoviral vectors for gene therapy has brought about the need for
new analytical tools. We have developed an anion-exchange high-performance liquid …

Replicating adenoviruses may prove to be effective anticancer agents if they can be engineered
to selectively destroy tumor cells. We have constructed a virus (01/PEME) containing a …

Multiplicity of infection is commonly defined as the ratio of infectious virions to cells in a culture.
On the surface, the concept is simple, easy to calculate, and easy to use in speech and …

Reports suggest a role of calpains in degradation of wild-type p53, which may regulate p53
induction of apoptosis. A calpain inhibitor, n-acetyl-leu-leu-norleucinal (calpain inhibitor 1), …

Background Zika virus (ZIKV), a mosquito-borne flavivirus, is a re-emerging virus that constitutes
a public health threat due to its recent global spread, recurrent outbreaks, and infections …

Smad proteins transduce signals carried by the transforming growth factor β (TGF-β)
cytokine superfamily from receptor serine/threonine kinases at the cell surface to the nucleus, …

Recombinant adenoviral (rAd) vectors are capable of mediating high-efficiency gene transfer
in vivo. Under conditions requiring systemic administration, however, the use of rAd vectors …

The FDA-approved Adenovirus Type 4 and Type 7 Vaccine, Live, Oral is highly effective and
essential in preventing acute respiratory diseases (ARDs) in US military recruits. Our study …