Degradation of the surfactant polysorbate (PS) by enzyme impurities has been previously
suggested as a mechanism for the formation of visible and subvisible particles that affect …

Purpose Enzymatic polysorbate (PS) degradation and resulting free fatty acid (FFA) particles
are detrimental to biopharmaceutical drug product (DP) stability. Different types and grades …

Weak protein-protein interactions are thought to modulate the viscoelastic properties of
concentrated antibody solutions. Predicting the viscoelastic behavior of concentrated antibodies …

The conjugation of hydrophobic cytotoxic agents such as monomethyl auristatin E (MMAE)
to the interchain sulfhydryl groups of monoclonal antibodies (Mabs) through a protease-labile …

Antibody drug conjugates enable the targeted delivery of potent chemotherapeutic agents
directly to cancerous cells. They are made by the chemical conjugation of cytotoxins to …

Conjugation of an antibody to a drug can produce heterogeneous species that may have
different physical stabilities and safety profiles. We explored the effect of thermal stress on the …

… Pervina Kei and John Wang are acknowledged for kindly providing enzymatically digested
polysorbate 20 samples. Kevin Lu is acknowledged for his support with the HPLC analysis. …

… from gRED Center of Advance Light Microscopy for the facility setup; Catherine Shi for
showing me around and teaching me all the tricks; and Eileen, Nate, Michelle, Kate, and Pervina …

Surfactants such as Poloxamer 188 (PX188) play an important role in controlling particle
formation in biotherapeutic formulations due to interfacial stresses. This study demonstrates for …

This volume provides a new critical text of the Prologue and the first two books of Venantius
Fortunatus' Vita Sancti Martini, a work, written in the latter half of the sixth century, which …