Molecular and Biological Analysis of Eight Genetic Islands That Distinguish Neisseria meningitidis from the Closely Related Pathogen Neisseria gonorrhoeae

SR Klee, X Nassif, B Kusecek, P Merker… - Infection and …, 2000 - Am Soc Microbiol
The pathogenic species Neisseria meningitidis andNeisseria gonorrhoeae cause dramatically
different diseases despite strong relatedness at the genetic and biochemical levels.N. …

Two‐dimensional structure of the Opc invasin from Neisseria meningitidis

P Merker, J Tommassen, B Kusecek… - Molecular …, 1997 - Wiley Online Library
A two‐dimensional structural model was devised for the Opc outer membrane protein
invasin which contains 10 transmembrane strands and five surface‐exposed loops. One …

Challenges Encountered in the Implementation of Bio-Fluorescent Particle Counting Systems as a Routine Microbial Monitoring Tool

…, J Salvas, M Dingle, P Hutchins, P Merker… - PDA Journal of …, 2023 - journal.pda.org
The transition from traditional growth-based microbial detection methods to continuous bio-fluorescent
particle counting methods represents a paradigm shift, because the results will be …

Alternative microbial testing: a novel DNA-based detection system for specified microorganisms in pharmaceutical preparations

P Merker, L Grohmann, R Petersen… - PDA Journal of …, 2000 - journal.pda.org
Fluorescence-coupled PCR technology was employed to quantify DNA segments specific
for Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacteriaceae. The PCR …

Understanding the Non-Equivalency of Bio-Fluorescent Particle Counts versus the Colony-Forming Unit

J Salvas, P Merker, M Dingle, C Joossen… - PDA Journal of …, 2023 - journal.pda.org
Adopting emerging microbiological methods is often desirable because it enables more
advantageous, real-time monitoring practices. However, when the newer method measures …

[HTML][HTML] Opinion: Revisit Regulatory Expectations for Micro ID in Grade A Environments for Non-growth-based Methods?

P Merker, AG Bayer, T Cundell… - chapters.pda.org
Biofluorescent particle counters (BFPCs) allow for the detection and enumeration of
microorganisms in the environment and rely on intrinsic fluorescence detection instead of growth, …

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

…, PJ Zwijnenburg, M Vikkula, S Schulte-Merker… - Nature …, 2009 - nature.com
Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics
define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a …

Endothelial cell–specific FGD5 involvement in vascular pruning defines neovessel fate in mice

…, I Chrifi, EAL Biessen, S Dimmeler, S Schulte-Merker… - Circulation, 2012 - Am Heart Assoc
Background— New vessel formation contributes to organ development during embryogenesis
and tissue repair in response to mechanical damage, inflammation, and ischemia in adult …

Effects of the cytostatic drug cis‐platinum on the developing neocortex of the mouse

P Köpf‐Maier, HJ Merker - Teratology, 1983 - Wiley Online Library
The effects of the new cytostatic drug cis‐diamminedichloro‐platinum(II) (cis‐platinum) on
the developing neocortex of NMRI mouse embryos or fetuses were investigated using light‐ …

Raman spectroscopic identification of Mycobacterium tuberculosis

…, S Dees, E Richter, S Andres, M Merker… - Journal of …, 2017 - Wiley Online Library
In this study, Raman microspectroscopy has been utilized to identify mycobacteria to the
species level. Because of the slow growth of mycobacteria, the per se cultivation‐independent …