User profiles for Philippe Lam
Philip W. LamUniversity of Toronto Verified email at sunnybrook.ca Cited by 399 |
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid–based proteasome inhibitors
EB Golden, PY Lam, A Kardosh… - Blood, The Journal …, 2009 - ashpublications.org
The anticancer potency of green tea and its individual components is being intensely
investigated, and some cancer patients already self-medicate with this “miracle herb” in hopes of …
investigated, and some cancer patients already self-medicate with this “miracle herb” in hopes of …
Surface-tension-confined microfluidics
Traditionally, microfluidic devices are constructed by photolithographic methods using silicon
or glass substrates, 1 by rapid prototyping of poly (dimethylsiloxane) elastomers, 2 or by …
or glass substrates, 1 by rapid prototyping of poly (dimethylsiloxane) elastomers, 2 or by …
[HTML][HTML] Hepatitis B in sub-Saharan Africa: strategies to achieve the 2030 elimination targets
…, N Gogela, C Kassianides, M Kew, P Lam… - The lancet …, 2017 - thelancet.com
The WHO global health sector strategy on viral hepatitis, created in May, 2016, aims to
achieve a 90% reduction in new cases of chronic hepatitis B and C and a 65% reduction in …
achieve a 90% reduction in new cases of chronic hepatitis B and C and a 65% reduction in …
Protein aggregation in frozen trehalose formulations: effects of composition, cooling rate, and storage temperature
…, MEM Cromwell, JMR Moore, P Lam - Journal of …, 2015 - Elsevier
This study was designed to assess the effects of cooling rate, storage temperature, and
formulation composition on trehalose phase distribution and protein stability in frozen solutions. …
formulation composition on trehalose phase distribution and protein stability in frozen solutions. …
AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors
…, JA Gorski, ES Gibson, P Lam… - Journal of …, 2012 - Soc Neuroscience
AMPA receptors (AMPARs) are tetrameric ion channels assembled from GluA1–GluA4
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …
Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A (H1N1) virus pneumonia
…, KT Wong, KW Choi, GM Joynt, P Lam… - Antiviral …, 2011 - journals.sagepub.com
Background Little is known about the virological and inflammatory responses of severe
pandemic 2009 influenza A(H1N1) virus pneumonia during antiviral treatment. Methods In a …
pandemic 2009 influenza A(H1N1) virus pneumonia during antiviral treatment. Methods In a …
c‐Jun N‐terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
Q Zhou, PY Lam, D Han… - Journal of …, 2008 - Wiley Online Library
This study examines the role of c‐jun N‐terminal kinase (JNK) in mitochondrial signaling and
bioenergetics in primary cortical neurons and isolated rat brain mitochondria. Exposure of …
bioenergetics in primary cortical neurons and isolated rat brain mitochondria. Exposure of …
Development of a decision support system for air-cargo pallets loading problem: A case study
This paper presents a two-phase intelligent Decision Support System (DSS) for Air-Cargo
Loading Problem (ACLP). This problem can also be viewed as three dimensional, non-…
Loading Problem (ACLP). This problem can also be viewed as three dimensional, non-…
[HTML][HTML] Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
Mitochondrial dysfunction is often associated with aging and neurodegeneration. c-Jun-N-terminal
kinase (JNK) phosphorylation and its translocation to mitochondria increased as a …
kinase (JNK) phosphorylation and its translocation to mitochondria increased as a …
Hepatocellular carcinoma: measures to improve the outlook in sub-Saharan Africa
…, L Katsidzira, A Kramvis, P Lam… - The Lancet …, 2022 - thelancet.com
Hepatocellular carcinoma is a leading public health concern in sub-Saharan Africa, and it is
most prevalent in young adults (median 45 years [IQR 35–57]). Overall, outcomes are poor, …
most prevalent in young adults (median 45 years [IQR 35–57]). Overall, outcomes are poor, …