User profiles for Philippe Lam

Philip W. Lam

University of Toronto
Verified email at sunnybrook.ca
Cited by 399

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid–based proteasome inhibitors

EB Golden, PY Lam, A Kardosh… - Blood, The Journal …, 2009 - ashpublications.org
The anticancer potency of green tea and its individual components is being intensely
investigated, and some cancer patients already self-medicate with this “miracle herb” in hopes of …

Surface-tension-confined microfluidics

P Lam, KJ Wynne, GE Wnek - Langmuir, 2002 - ACS Publications
Traditionally, microfluidic devices are constructed by photolithographic methods using silicon
or glass substrates, 1 by rapid prototyping of poly (dimethylsiloxane) elastomers, 2 or by …

[HTML][HTML] Hepatitis B in sub-Saharan Africa: strategies to achieve the 2030 elimination targets

…, N Gogela, C Kassianides, M Kew, P Lam… - The lancet …, 2017 - thelancet.com
The WHO global health sector strategy on viral hepatitis, created in May, 2016, aims to
achieve a 90% reduction in new cases of chronic hepatitis B and C and a 65% reduction in …

Protein aggregation in frozen trehalose formulations: effects of composition, cooling rate, and storage temperature

…, MEM Cromwell, JMR Moore, P Lam - Journal of …, 2015 - Elsevier
This study was designed to assess the effects of cooling rate, storage temperature, and
formulation composition on trehalose phase distribution and protein stability in frozen solutions. …

AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors

…, JA Gorski, ES Gibson, P Lam… - Journal of …, 2012 - Soc Neuroscience
AMPA receptors (AMPARs) are tetrameric ion channels assembled from GluA1–GluA4
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …

Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A (H1N1) virus pneumonia

…, KT Wong, KW Choi, GM Joynt, P Lam… - Antiviral …, 2011 - journals.sagepub.com
Background Little is known about the virological and inflammatory responses of severe
pandemic 2009 influenza A(H1N1) virus pneumonia during antiviral treatment. Methods In a …

c‐Jun N‐terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons

Q Zhou, PY Lam, D Han… - Journal of …, 2008 - Wiley Online Library
This study examines the role of c‐jun N‐terminal kinase (JNK) in mitochondrial signaling and
bioenergetics in primary cortical neurons and isolated rat brain mitochondria. Exposure of …

Development of a decision support system for air-cargo pallets loading problem: A case study

…, R Bhagwat, N Kumar, MK Tiwari, P Lam - Expert Systems with …, 2006 - Elsevier
This paper presents a two-phase intelligent Decision Support System (DSS) for Air-Cargo
Loading Problem (ACLP). This problem can also be viewed as three dimensional, non-…

[HTML][HTML] Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

Q Zhou, PY Lam, D Han, E Cadenas - FEBS letters, 2009 - Elsevier
Mitochondrial dysfunction is often associated with aging and neurodegeneration. c-Jun-N-terminal
kinase (JNK) phosphorylation and its translocation to mitochondria increased as a …

Hepatocellular carcinoma: measures to improve the outlook in sub-Saharan Africa

…, L Katsidzira, A Kramvis, P Lam… - The Lancet …, 2022 - thelancet.com
Hepatocellular carcinoma is a leading public health concern in sub-Saharan Africa, and it is
most prevalent in young adults (median 45 years [IQR 35–57]). Overall, outcomes are poor, …