Rituxan (Rituximab) is a chimeric mAb with human IgG1 constant domains used in the
therapy of non-Hodgkin’s B cell lymphomas. This Ab targets B cells by binding to the cell-surface …

This manuscript describes two sites in a human IgG1 that, when mutated individually or in
combination, result in a dramatic increase in C1q binding and complement-dependent …

Antibody charge variants have gained considerable attention in the biotechnology industry
due to their potential influence on stability and biological activity. Subtle differences in the …

Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately
measured using an appropriate relative potency bioassay. Developing a bioassay is a complex, …

The physical/chemical stability and potential interactions after diluting two immunoglobulin
G1 monoclonal antibodies (mAb), pertuzumab (Perjeta®) and trastuzumab (Herceptin®), in a …

Multivariable calculus is one of the core subjects which engineering students study at university.
Students may end up memorizing formulae in multivariable calculus due to the lack of …

Due to their potential influence on stability, pharmacokinetics, and product consistency,
antibody charge variants have attracted considerable attention in the biotechnology industry. …

In today’s fast, globalised world, lubrication has become essential in enhancing engine
efficiency, including in the marine sector. While the number of fishing vessels increased, so did …

This paper describes in detail the dermatological, medical, and laboratory findings of patients
poisoned with PCBs and related compounds in Taiwan. Together with their symptoms, …

T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that
recruit a patient’s T cells to kill cancer cells. There are increasing numbers of TBDs in clinical …