Poloxamer (Pluronic®) nonionic surfactant vehicles are a series of chemically-related block
copolymers finding widespread use in parenteral formulations as solubilizing and wetting …

Thalidomide is reported to have therapeutic utility in the treatment of pyoderma gangrenosum,
Behçet’s disease, aphthous ulcers, and skin wounds. We investigated the effect of …

Background and design: Viable tissue is essential to assess the rate and extent of biotransformation
during percutaneous absorption in vitro. We assessed the viability of hairless mouse …

The objective of this study was to develop a method of preparing mouse stratum corneum/epidermal
(SCE) tissue without the dermis for use in drug diffusion studies. The diffusion of …

The anaerobic metabolism of verapamil was studied to determine the role the intestinal flora
may have on the disposition of verapamil. Metabolites produced by the flora could be the …

The objectives of this study were to investigate the absorption of diazepam applied topically
to the hairless mouse in vivo and to determine the diffusion of diazepam across isolated …

The activities of prolyl hydroxylase (Pro-OHase), galactosylhydroxylysyl glucosyltransferase
(Glu-Gal-Hyl-Tase), and hydroxylysyl galactosyltransferase (Gal-Hyl-Tase) were assayed in …

Thalidomide (T) is a powerful therapeutic agent for pyoderma gangrenosum and other skin
wounds. We investigated the effect of T on human keratinocyte (HK) proliferation, migration, …

Poloxamer (Pluronicº) nonionic surfactant vehicles are a series of chemically-related block
copolymers finding widespread use in parenteral formulations as solubilizing and wetting …

… We also acknowledge the technical help of Hewitt employees Lonnie Lee Buresh and Prema
Palicharla. Outside of Hewitt, we benefited from the suggestions of Michael Kremer, Andrei …