This review addresses current understanding of oxygen radical mechanisms as they relate
to the brain during ischemia and reperfusion. The mechanism for radical production remains …

Moment-to-moment changes in local neuronal activity lead to dynamic changes in cerebral
blood flow. Emerging evidence implicates astrocytes as one of the key players in …

Relapse is common in substance use disorders (SUDs), even among treated individuals.
The goal of this article was to systematically review the existing evidence on mindfulness …

Digital PCR enables the absolute quantitation of nucleic acids in a sample. The lack of
scalable and practical technologies for digital PCR implementation has hampered the …

The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster
Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the first time …

Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays
a prominent role in various of models of cellular injury. Here, we identify poly(ADP-ribose) (…

The prognostic value of MRD in large series of childhood T-ALL has not yet been established.
Trial AIEOP-BFM-ALL 2000 introduced standardized quantitative assessment of MRD for …

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in
mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder …

The goals of this study were to quantify the effects of epinephrine on myocardial and
cerebral blood flow during conventional cardiopulmonary resuscitation (CPR) and CPR with …

Detection of minimal residual disease (MRD) is the most sensitive method to evaluate
treatment response and one of the strongest predictors of outcome in childhood acute …