Membrane capacity during the filtration of biotech process streams is typically limited by
fouling, which can occur by pore blocking, pore constriction, caking or a combination of the …

Conventional tangential flow filtration (TFF) has traditionally been limited to separation of
solutes that differ by about ten‐fold in size. Wide pore‐size distributions, membrane fouling, …

Several recent studies have reported a decline in virus retention during virus challenge filtration
experiments, although the mechanism(s) governing this phenomenon for different filters …

Highlights ► Confocal scanning laser microscopy method developed to study virus capture.►
Images obtained of fluorescently-labeled bacteriophage captured within virus filtration …

High-performance tangential flow filtration (HPTFF) is a new technology for protein and
nucleotide purification. Conventional ultrafiltration (UF) is limited to separation of solutes that …

The microfiltration performance of a novel membrane module design with helically wound
hollow fibers is compared with that obtained with a standard commercial‐type crossflow …

Depth filters are often used in biotechnology processes to remove cell debris from cell culture
solutions. A model of filter plugging was developed to allow predictions of required filter …

Dextran sieving (or retention) tests have become a standard method for characterizing the
pore size distribution of ultrafiltration membranes. The objective of this work was to extend this …

Drug sterility is a critical requirement in the pharmaceutical industry. Virus removal or
inactivation is also required for biologically derived therapeutics (eg, monoclonal antibodies, …

Ultrafiltration (UF) is a pressure-driven membrane process used throughout downstream
processing for: (1) protein concentration, (2) buffer exchange and desalting, (3) removal of …