This research study was designed to develop model extended-release (ER) matrix tablet
formulations for metoprolol tartrate (100 mg) sufficiently sensitive to manufacturing variables …

The objective of this study, was to examine the influence of critical formulation and processing
variables as described in the AAPS/FDA Workshop II report on scale-up of oral extended-…

Biodegradable microspheres were evaluated as vaccine adjuvants based on their ability to
provide prolonged release of incorporated agents. Hepatitis B surface antigen (HBSA) …

A quick and reproducible capillary electrophoresis method was optimized and validated for
the assay of bovine serum albumin (BSA). The effects of various parameters such as pH of …

A simple, precise, accurate and rugged reversed‐phase high‐performance liquid
chromatography (HPLC) method has been developed and validated for the simultaneous …

2584 Background: The Wnt signalling pathway is involved in cellular proliferation,
differentiation, migration and implicated in stem cell function in several cancers. ETC-159 is a …

In the last decade, drug development has tackled substantial challenges to improve
efficiency and facilitate access to innovative medicines. Integrated clinical protocols and the …

Currently there is considerable interest in the legislative debate around generic biological
drugs or “biosimilars” in the EU and US due to the large, lucrative market that it offers to the …

R1481 is a sub‐type selective muscarinic receptor antagonist with the potential treatment of
overactive bladder. R1481 presents two challenges for drug development. The first is the …

Introduction AOD01 is a novel, fully human immunoglobulin (Ig) G1 neutralizing monoclonal
antibody that was developed as a therapeutic against severe acute respiratory syndrome …