Use of PCR analysis for detecting low levels of bacteria and mold contamination in pharmaceutical samples

L Jimenez, S Smalls, R Ignar - Journal of microbiological methods, 2000 - Elsevier
PCR assays were developed and compared to standard methods for quality evaluation of
pharmaceutical raw materials and finished products with low levels of microbial contamination. …

Use of PCR analysis for sterility testing in pharmaceutical environments

L JIMENEZ, R IGNAR, R D'AIELLO… - Journal of Rapid …, 2000 - Wiley Online Library
To determine the sterility of pharmaceutical samples, highly conserved bacterial ribosomal
DNA sequences were used in a PCR‐based assay. Finished products, raw materials, growth …

Rapid detection of microbial contamination in triclosan and high fluoride dentifrices using an ATP bioluminescence assay

R IGNAR, D ENGLISH… - Journal of Rapid Methods …, 1998 - Wiley Online Library
The Celsis ATP Bioluminescence method was optimized and validated to detect the presence
of microbial contamination in High Fluoride and Triclosan dentifrice formulations. Several …

MOLECULAR DETECTION AND IDENTIFICATION OF ASPERGILLUS NIGER CONTAMINATION IN COSMETIC/PHARMACEUTICAL RAW MATERIALS AND …

…, Y BOSKO, S SMALLS, R IGNAR… - Journal of Rapid …, 1999 - Wiley Online Library
A PCR‐based assay using a one step sample preparation was developed and validated
against standard methods for the rapid detection of Aspergillus niger contamination in cosmetic/…

PCR detection of Salmonella typhimurium in Pharmaceutical raw materials and products Contaminated with a mixed bacterial culture using the BAX™ system

…, C Scalici, S Smalls, Y Bosko, R Ignar - PDA Journal of …, 2001 - journal.pda.org
The BAX™ system, a PCR-based assay, was evaluated for detecting Salmonella typhimurium
in pharmaceutical raw materials and products contaminated with mixed bacterial cultures …

Characterization and Analysis of The Nasal Microbiota and Plasmatic Extracellular Vesicles in Allergic Rhinitis: A Case-Control Study

…, S Iodice, L Cantone, P Marraccini, E Conforti, R Ignar… - 2020 - researchsquare.com
Background: Increasing evidence suggests a possible link between the bacterial nasal
microbiota (bNM) to allergic diseases such as allergic Rhinitis (AR), as it might modulate the …

[HTML][HTML] Sequence-based identification of microbial contaminants in non-parenteral products

R Senthilraj, GS Prasad, K Janakiraman - Brazilian Journal of …, 2016 - SciELO Brasil
… But PCR detects only the fixed target microorganism and it will not detect other microorganisms
of interest (Jimenez, Ignar, 2000JIMENEZ, L.; RAYMOND IGNAR, SS Use of PCR …

Apical membrane antigen 1 as an anti-malarial drug target

CA MacRaild, RF Anders, M Foley… - Current topics in …, 2011 - ingentaconnect.com
… interactions that 1F9 and the IgNAR make with AMA1. Subsets … In particular, residues L89,
F100 and R101 of the IgNAR … Conservative substitution of F100 in the high-affinity IgNAR 14I1…

Antibodies from other species

ML Vadnais, MF Criscitiello, VV Smider - Protein Therapeutics, 2017 - Wiley Online Library
… Surface IgNAR has one amino terminal variable domain. This single variable domain …
IgNAR also contains three or five constant domains determined by alternate splicing. IgNAR

Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen

J Oriol Sunyer - … -Drug Targets (Formerly Current Drug Targets …, 2012 - ingentaconnect.com
… Their B cells are known to secrete three types of antibodies, IgM, IgW and IgNAR. Teleost
fish are also called bony fish since they represent the most ancient living species containing …