Neuroinflammation is a hallmark of acute and chronic neurodegenerative disorders. The
main aim of this study was to evaluate the therapeutic efficacy of intranasal cationic …

The main objective of this study was to evaluate comparative biodistribution and pharmacokinetics
of cyclosporine-A (CsA) following intranasal (IN) administration versus intravenous (IV…

This article describes the role and responsibilities of the Developability Assessment Group (DAG),
a pharmaceutical Research and Development (R&D) subgroup, which supports drug …

The objective of this paper was to identify oral bioavailability enhancing approaches for a
poorly water-soluble research compound during drug discovery stages using minimal amounts …

New coprocessed excipients composed of α-lactose monohydrate (a filler), HPMC E3 (a
binder), and PVPP (a superdisintegrant) were developed by spray drying in this study to …

Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these
drugs is often associated with patient toxicity and poor tumor delivery. Micellar drug carriers …

This chapter summarizes the significance of suspension in preclinical development. Majority
of the preclinical studies are carried out using suspension. Therefore, it is important to know …

The purpose of this study is to confirm the impact of polar functional groups on inter and intra-molecular
hydrogen bonding in haloperidol (HP) and droperidol (DP) and, hence, their …

A co-crystal is defined as a single crystalline structure composed of two or more components
with no proton transfer which are solid at room temperature. Our group has come up with …

D-Cycloserine (DCS) is a broad-spectrum antibiotic that is currently FDA-approved to treat
tuberculosis (TB) disease and urinary tract infection (UTI). Despite numerous reports showing …