Multiple mitochondrial DNA deletions in an elderly human individual

C Zhang, A Baumer, RJ Maxwell, AW Linnane… - FEBS …, 1992 - Wiley Online Library
We have used the polymerase chain reaction (PCR) to study deletions in the mitochondrial
DNA (mtDNA) of an elderly human individual. An extended set of PCR primers has been …

Mitochondrial gene mutation: the ageing process and degenerative diseases.

AW Linnane, A Baumer, RJ Maxwell… - Biochemistry …, 1990 - europepmc.org
Polymerase chain reaction (PCR) amplification was carried out on total DNA from a range of
autopsy tissues from deceased human subjects with no known mitochondrial disease, aged …

Biogenesis of mitochondria: the mitochondrial gene (aap1) coding for mitochondrial ATPase subunit 8 in Saccharomyces cerevisiae

IG Macreadie, CE Novitski, RJ Maxwell… - Nucleic acids …, 1983 - academic.oup.com
A mitochondrial gene (denoted aap1) in Sacchaaromyces cerevisiae has been characterized
by nucleotide sequence analysis of a region of mtDNA between the oxi3 and oli2 genes. …

Mitochondrial DNA mutation associated with aging and degenerative disease.

…, IR Mackay, A Baumer, RJ Maxwell… - Annals of the New …, 1992 - europepmc.org
Previous theories of aging based on somatic mutation neglected mtDNA, which has a high
propensity for mutational error. Knowledge of yeast mtDNA mutations and their functional …

Varied prevalence of age-associated mitochondrial DNA deletions in different species and tissues: a comparison between human and rat

C Zhang, M Bills, A Quigley, RJ Maxwell… - Biochemical and …, 1997 - Elsevier
The prevalence in tissues of mtDNA deletions was compared by PCR between humans and
rats of similar “biological ages”. Pairs of species-specific primers were used which spanned …

Identification of a 66 KDa protein associated with yeast mitochondrial ATP synthase as heat shock protein hsp60

RE Gray, DG Grasso, RJ Maxwell, PM Finnegan… - FEBS …, 1990 - Wiley Online Library
A 66 kDa protein, denoted P66, not hitherto classified as an integral component of yeast
mitochondrial ATPase, is often observed in preparations of this enzyme complex. A physical …

Biogenesis of Mitochondria: Genetic and molecular analysis of the oli2 region of mitochondrial DNA in Saccharomyces cerevisiae

CE Novitski, IG Macreadie, RJ Maxwell, HB Lukins… - Current genetics, 1984 - Springer
A genetic and molecular analysis of the oli2 region in mitochondrial DNA of Saccharomyces
cerevisiae has been carried out. The oli2 gene codes for subunit 6 of the mitochondrial …

Standard particulate sets for visual inspection systems: their preparation, evaluation, and applications

SJ Borchert, RJ Maxwell, RL Davison… - PDA Journal of …, 1986 - journal.pda.org
This article describes some standard particulate sets for visual inspection systems. Methods
for preparation of the sets are presented along with three nondestructive techniques for …

Subunit 8 of yeast mitochondrial ATP synthase: biochemical genetics and membrane assembly

P Nagley, RJ Devenish, RHP Law, RJ Maxwell… - Bioenergetics: Molecular …, 1990 - Springer
Subunit 8 is a small integral membrane protein of the proton-translocating F 0 sector of the
mitochondrial ATP synthase complex. We here review our current understanding of the …

Mitochondrial mutations and the ageing process

…, A Boubolas, R Martinus, RJ Maxwell… - Adenine nucleotides in …, 1992 - Springer
We have proposed that the accumulation of random somatic gene mutations in the
mitochondrial DNA (mtDNA) during life is an important contributor to the ageing process. The …