User profiles for Sagar Dhamane
 | sagar dhamaneMerck Verified email at uh.edu Cited by 384 |
Unified superresolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations
Chromatographic protein separations, immunoassays, and biosensing all typically involve the
adsorption of proteins to surfaces decorated with charged, hydrophobic, or affinity ligands. …
adsorption of proteins to surfaces decorated with charged, hydrophobic, or affinity ligands. …
[HTML][HTML] Sensitive detection of norovirus using phage nanoparticle reporters in lateral-flow assay
Noroviruses are recognized worldwide as the principal cause of acute, non-bacterial
gastroenteritis, resulting in 19-21 million cases of disease every year in the United States. …
gastroenteritis, resulting in 19-21 million cases of disease every year in the United States. …
Aptamer-phage reporters for ultrasensitive lateral flow assays
We introduce the modification of bacteriophage particles with aptamers for use as bioanalytical
reporters, and demonstrate the use of these particles in ultrasensitive lateral flow assays. …
reporters, and demonstrate the use of these particles in ultrasensitive lateral flow assays. …
High ionic strength narrows the population of sites participating in protein ion-exchange adsorption: A single-molecule study
The retention and elution of proteins in ion-exchange chromatography is routinely controlled
by adjusting the mobile phase salt concentration. It has repeatedly been observed, as …
by adjusting the mobile phase salt concentration. It has repeatedly been observed, as …
[HTML][HTML] Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays
Two types of viral nanoparticles were functionalized with target-specific antibodies and
multiple copies of an enzymatic reporter (horseradish peroxidase). The particles were …
multiple copies of an enzymatic reporter (horseradish peroxidase). The particles were …
Detection of viruses by counting single fluorescent genetically biotinylated reporter immunophage using a lateral flow assay
We demonstrated a lateral flow immunoassay (LFA) for detection of viruses using fluorescently
labeled M13 bacteriophage as reporters and single-reporter counting as the readout. …
labeled M13 bacteriophage as reporters and single-reporter counting as the readout. …
[HTML][HTML] The emerging roles of steroid hormone receptors in ductal carcinoma in situ (DCIS) of the breast
H Villanueva, S Grimm, S Dhamne… - Journal of Mammary …, 2018 - Springer
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to most types of invasive breast
cancer (IBC). Although it is estimated only one third of untreated patients with DCIS will …
cancer (IBC). Although it is estimated only one third of untreated patients with DCIS will …
Competitive multicomponent anion exchange adsorption of proteins at the single molecule level
We use single molecule spectroscopy to study a multicomponent, competitive protein adsorption
system. Fluorescently-labeled α-lactalbumin proteins are super-resolved adsorbing to …
system. Fluorescently-labeled α-lactalbumin proteins are super-resolved adsorbing to …
Targeting the pro-survival protein BCL-2 to prevent breast cancer
This study demonstrates that prophylactic treatment with the BCL2-specific antagonist venetoclax
prevents breast cancer initiated by a mutated and activated PIK3CA, the most common …
prevents breast cancer initiated by a mutated and activated PIK3CA, the most common …
Biophysical characterization of VEGF–aHt DNA aptamer interactions
… ; Sagar Dhamane performed experiments; Loren J. Stagg performed experiments, and
participated in interpreting data and writing the manuscript; John E. Ladbury participated in …
participated in interpreting data and writing the manuscript; John E. Ladbury participated in …