There is increasing evidence that uncultivated bacterial symbionts are the true producers of
numerous bioactive compounds isolated from marine sponges. The localization and …

The fascaplysin class of compounds have been further investigated from six organisms
consisting of four sponge collections (Fascaplysinopsis reticulata) and two tunicate collections (…

We report herein the first example of a cytochrome P450-catalyzed oxidative carbon–carbon
coupling process for a scalable entry into arylomycin antibiotic cores. Starting from wild-type …

With many bioactive non-ribosomal peptides and polyketides produced in fungi, studies of
their biosyntheses are an active area of research. Practical limitations of working with mega-…

Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large
enzymes responsible for the biosynthesis of medically and ecologically important secondary …

Enzyme screening of crude sponge extracts prioritized a 2005 Papua New Guinea collection
of Hyrtios sp. for further study. The MeOH extract contained puupehenone and four …

Nuclear magnetic resonance (NMR) data from NOESY (nuclear Overhauser enhancement
spectroscopy) and ROESY (rotating frame Overhauser enhancement spectroscopy) …

The presence of fluorine in an active pharmaceutical ingredient ( API ) can impart important
pharmacological attributes with regards to metabolism, stability, and selectivity. As such, …

Actinobacteria such as streptomycetes are renowned for their ability to produce bioactive
natural products including nonribosomal peptides (NRPs) and polyketides (PKs). The advent of …

The goal of this study was to isolate and study additional jasplakinolide analogues from two
taxonomically distinct marine sponges including two Auletta spp. and one Jaspis splendens. …