Several hypotheses have explicitly implicated the role of an altered redox status of melanin
in the aetiology of melanoma and macular degeneration. The balance between the intrinsic …

A 'blockchain'is a distributed public consensus system that maintains an immutable record of
transactions on the web, incapable of being

The International Pharmaceutical Excipients Council defines excipients as substances, other
than the active drug substance of finished dosage form, which have been appropriately …

* To whom all correspondence should be addressed. uffers used to formulate proteins
should not serve as substrates or inhibitors. They should exhibit little or no change in pH with …

Signaling pathways that upregulate melanization in the retinal pigment epithelium (RPE) may
also be implicated in the downregulation of rod outer segment (ROS) phagocytosis by the …

Amphiphilic excipients such as surfactants, have been shown to be inhibitors of the multidrug
resistance (MDR) efflux pump transporter protein, P-glycoprotein (Pgp). In vitro studies …

The state of aggregation of the polymer melanin may determine its propensity to act either
as an antioxidant or as a pro-oxidant. Age-related alterations in its state of aggregation are …

Library of Congress Control Number: 2008937240 cс Humana Press, a part of Springer
Science+ Business Media, LLC 2009

There remains a paucity of predictive models to evaluate excipient or excipient mixture suitability
for dry powder inhalers because a large number of interdependent variables affect both …

The adoption of cocrystals into oral pharmaceutical formulations is expected to propel this,
as yet, moribund field into clinical and monetary prominence. The increase in resources and …