Benzyl alcohol, an antimicrobial preservative, accelerates aggregation and precipitation of
recombinant human interleukin‐1 receptor antagonist (rhIL‐1ra) in aqueous solution. The …

A major limitation in the successful development of multidose protein formulations is protein
aggregation induced by antimicrobial preservatives such as benzyl alcohol, which are …

The critical role played by temperature in ligand-induced protein aggregation was investigated.
Recombinant human interleukin-1 receptor antagonist (rhIL-1ra) and the ligands benzyl …

We evaluated the effect of UV-B light at 302 nm on a model therapeutic protein, 2.6 D type I
soluble tumor necrosis factor receptor (sTNF-RI). This protein contains a single Trp at …

We present Barrier-based Simplex (Bb-Simplex), a new, provably correct design for runtime
assurance of continuous dynamical systems. Bb-Simplex is centered around the Simplex …

This chapter introduces AI‐Grid: Artificial Intelligence (AI) enabled, provably resilient networked
microgrids. We present a programmable platform that integrates reliable AI modeling …

We present the Distributed Simplex Architecture (DSA), a new runtime assurance technique
that provides safety guarantees for multi-agent systems (MASs). DSA is inspired by the …

The purpose of this study was to evaluate the importance of prelyophilization solution pH on
the stability of botulinum neurotoxin, serotype A (rBoNTA(H c )). This understanding is of …

The present study evaluates the effects of excipients, compression pressure, and relative
humidity (RH) on the stability of sulfamerazine polymorphs (referred here as SMZ I and SMZ II) …

We explore the thermal light sterile neutrino situation from cosmological perspective in the $$\Lambda
\text {CDM} + r_{0.05} + N_{\text {eff}} + m^{\text {eff}}_{\text {s}}$$ Λ CDM + r 0.05 …