Alternative non‐B form DNA structures, also called secondary structures, can form in certain
DNA sequences under conditions that produce single‐stranded DNA, such as during …

Background. Polycyclic aromatic hydrocarbons (PAHs) emitted from combustion sources
are known to be mutagenic, with more potent species also being carcinogenic. Previous …

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human
metaphase chromosomes under replication stress and are often deleted in cancer cells. We …

Fork stabilization at DNA impediments is key to maintaining replication fork integrity and
preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the …

Although DNA repair is known to impact susceptibility to cancer and other diseases, relatively
few population studies have been performed to evaluate DNA repair kinetics in people …

DNA damage can be cytotoxic and mutagenic, and it is directly linked to aging, cancer, and
other diseases. To counteract the deleterious effects of DNA damage, cells have evolved …

Frailty is an age-related syndrome characterized by reduced recovery from stressors and
increased risks of morbidity and mortality. Although frailty is usually studied in those over 65 …

Exposure to DNA damaging agents can lead to mutations that cause cancer. The liver is
particularly vulnerable because it contains high levels of Cytochrome P450 enzymes that can …

Demonstration of effective and consistent viral clearance by small scale models of downstream
processing, typically cited as logarithmic reduction value (LRV), is an important safety …

Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput
options are not available. The CometChip was previously developed using mammalian …