Citrulline possesses a highly specific metabolism that bypasses splanchnic extraction because
it is not used by the intestine or taken up by the liver. The administration of citrulline may …

Griseofulvin is an antifungal agent with poor solubility and low bioavailability. The aim of this
work was to prepare poly-ɛ-caprolactone nanospheres and nanocapsules of griseofulvin …

The two halophyte plants Mesembryanthemum crystallinum and Carpobrotus edulis (Family:
Aizoaceae, Order: Cary-ophyllales), widely used in the traditional medicine, were chosen …

The aim of this work was to elaborate a novel approach for the development and optimization
of self-emulsifying drug delivery system (SEDDS), using response surface methodology …

The aim of the present study was to develop and characterize a resveratrol self-emulsifying
drug delivery system (Res-SEDDS), and to compare the uptake of resveratrol by bovine …

The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS)
to improve the transcorneal permeability of voriconazole. A ‘mixture design around a …

Purpose. Oral drug administration remains the most common and most convenient way used
in clinical therapy. The availability of a simple, rapid, economic and reproducible in vitro …

Recent years have witnessed the emergence of nanotechnology in the medicinal field in order
to improve existing treatments and develop novel and efficient therapies. Nanostructured …

Recently, we developed a new approach to rationalize an optimized design for self-emulsifying
drug delivery system (SEDDS) by introducing the HLB and the response surface as …

Objectives Clopidogrel, a thienopyridine antiplatelet agent, is a poor aqueous soluble
compound and a P-glycoprotein (P-gp) efflux pump substrate. These two factors are responsible …