Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation

SL Hem, H HogenEsch - Expert review of vaccines, 2007 - Taylor & Francis
Aluminum-containing adjuvants are an important component of many vaccines because
they safely potentiate the immune response. The structure and properties of aluminum …

The effect of ultrasonic vibrations on crystallization processes

SL Hem - Ultrasonics, 1967 - Elsevier
… The insonation of solidifying metals produces ingots that are fine-grained, dense, and
homogeneous.l The use of ultrasonic energy during the crystallization of supercooled melts …

Structure and properties of aluminum-containing adjuvants

SL Hem, JL White - Vaccine Design: The subunit and adjuvant approach, 1995 - Springer
The use of aluminum-containing adjuvants originated in 1926 with the observations of Glenny
et al. (1926) that an alum-precipitated diphtheria vaccine had greater antigenic properties …

Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro

…, D Jiang, H HogenEsch, JP Robinson, SL Hem - Vaccine, 2005 - Elsevier
An important step in the induction of an immune response to vaccines is the internalization
of antigens by antigen presenting cells, such as dendritic cells (DCs). Many current vaccines …

In vivo absorption of aluminium-containing vaccine adjuvants using 26Al

RE Flarend, SL Hem, JL White, D Elmore, MA Suckow… - Vaccine, 1997 - Elsevier
Aluminium hydroxide (AH) and aluminium phosphate (AP) adjuvants, labelled with 26 Al,
were injected intramuscularly (im) in New Zealand White rabbits. Blood and urine samples …

Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants

A Sokolovska, SL Hem, H HogenEsch - Vaccine, 2007 - Elsevier
Aluminum-containing adjuvants are widely used in licensed human and veterinary vaccines.
However, the mechanism by which these adjuvants enhance the immune response and …

Aluminum compounds used as adjuvants in vaccines

…, RL Hutchinson, DL Perry, JL White, SL Hem - Pharmaceutical …, 1990 - Springer
The structure of nine commercially manufactured aluminum-containing adjuvants was
investigated by X-ray diffraction, infrared spectroscopy, transmission electron micrography, and …

Mechanism of adsorption of clindamycin and tetracycline by montmorillonite

LS Porubcan, CJ Serna, JL White, SL Hem - Journal of Pharmaceutical …, 1978 - Elsevier
IR and X-ray analyses of the interaction of clindamycin with montmorillonite indicate that
clindamycin is adsorbed by a cation-exchange mechanism under pH conditions favoring the …

Predicting the adsorption of proteins by aluminium-containing adjuvants

SJ Seeber, JL White, SL Hem - Vaccine, 1991 - Elsevier
The adsorption of two model proteins, albumin and lysozyme, by boehmite or amorphous
aluminium hydroxyphosphate adjuvants was studied. Electrostatic attraction has a major role …

Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants

IZR Méndez, Y Shi, H HogenEsch, SL Hem - Vaccine, 2007 - Elsevier
The degree of antigen adsorption by aluminum-containing adjuvants is considered an
important characteristic of vaccines that is related to immunopotentiation by the adjuvant. This …