We investigated the role of Bruton's tyrosine kinase (Btk) in FcεRI-dependent activation of
mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, mast cell …

Protein-tyrosine kinases play crucial roles in mast cell activation through the high-affinity IgE
receptor (FcεRI). In this study, we have made the following observations on growth …

The STAT (signal transducer and activator of transcription) proteins play a crucial role in the
regulation of gene expression, but their targets and the manner in which they select them …

Mast cells derived from Bruton’s tyrosine kinase (Btk)-defective xid or btk null mice showed
greater expansion in culture containing interleukin-3 (IL-3) than those from wild-type (wt) mice…

Bruton’s tyrosine kinase (Btk) plays pivotal roles in mast cell activation as well as in B cell
development. Btk mutations lead to severe impairments in proinflammatory cytokine production …

Stimulation of the high affinity IgE receptor (FcεRI) as well as a variety of stresses induce
activation of c-Jun N-terminal protein kinases (JNKs) stress-activated protein kinases in mast …

Two protein-tyrosine kinases, Bruton's tyrosine kinase (Btk) and Syk, and members of the
protein kinase C (PKC) subfamily of serine/threonine kinases play crucial roles in signal …

Cross-linking of the high affinity IgE receptor (FcεRI) on mast cells induces secretion of
cytokines, including interleukin (IL)-2, through transcriptional activation of cytokine genes. …

Defects in Bruton's tyrosine kinase (Btk) result in B cell immunodeficiencies in humans and
mice. Recent studies showed that Btk is required for maximal activation of JNK, a family of …

Relative potency assays for biological therapeutics require statistical evaluation to
demonstrate similarity between the dose–response curves of a reference standard and the test …