Reports suggest that Alzheimer’s disease (AD) patients show a high life-time prevalence of
seizure-like disorders. The transgenic CRND8 (TgCRDN8) is a mouse model of AD-like …

INTRODUCTION: Drug-induced prolongation of the QT interval via block of the hERG
potassium channel is a major cause of attrition in drug development. The advent of automated …

Human diseases may involve cellular signaling networks that contain redundant pathways,
so that blocking a single pathway in the system cannot achieve the desired effect. As such, …

A Monte Carlo method of computing unbiased estimating equations for the analysis of data
measured with error is described. Asymptotic distribution results are obtained for estimators …

Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes
and drug-induced toxicity. The pharmaceutical industry is challenged with identifying …

Parallelism is a prerequisite for the determination of relative potency in bioassays. It involves
testing of similarity between a pair of dose–response curves of a reference standard and a …

GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity
against bacteria associated with community-acquired pneumonia and skin infections. We have …

Validation of linearity is a regulatory requirement. Although many methods are proposed,
they suffer from several deficiencies including difficulties of setting fit-for-purpose acceptable …

Clinical trials of the first approved integrase inhibitor (INI), raltegravir, have demonstrated a
drop in the human immunodeficiency virus type 1 (HIV-1) RNA loads of infected patients that …

A method for detecting deviations from the Loewe additive drug combination reference
model for in vitro drug combination experimentation is described. It is often difficult to fit a …