The pro-inflammatory cytokine interleukin (IL)-6 (refs. 1–5) can bind to cells lacking the IL-6
receptor (IL-6R) when it forms a complex with the soluble IL-6R (sIL-6R)(trans signaling) 5, 6, …

Signal transduction in response to interleukin‐6 (IL‐6) requires binding of the cytokine to its
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …

… Walchek B, Kahn J, Fisher JM, Wang BB, Fisk RS, Payan DG, Feehan C, Betageri R, Darlak K,
Spatola SF, Kishimoto T K. 1996. Neutrophil rolling altered by inhibition of … A metalloprotease …

… Consequently, an increase of CD68-positive mononuclear cells and CD3-positive T cells in
intestinal tissue sections of DSS-treated ADAM17 ex/ex animals was detected (Fig. S5, F and …

NB, JG, JEM and AP originated the concept of the study. HL contributed the chromosome
sorting strategy. The project was further developed by WEB, DM, TJ, ML and BHKB, TN, AT and …

Background The connection of the variable part of the heavy chain (VH) and and the variable
part of the light chain (VL) by a peptide linker to form a consecutive polypeptide chain (…

Background & Aims: Liver regeneration after loss of hepatic tissue leads to hepatocyte and
nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Interleukin (IL)-6 …

Monoclonal antibodies (Mab) are the fastest growing group of biopharmaceuticals in
development. For production in mammalian cells, the four polypeptide chains of the …

We introduce a procedure for the rapid generation of fully human antibodies derived from “Fab-on-phage”
display libraries. The technology is based on the compatibility of display …

… Beside neoplasms, expression of CD30 in normal cells is restricted to activated B and T
lymphocytes with no expression on nonhematolymphoid cells and resting hematolymphoid cells. …