To the Editor: Since the first marketing approvals of recombinant biopharmaceuticals, the
question of which changes in quality attributes, which comprise identity, strength and purity, are …

… Using two independent samples t-tests and a Pearson correlation, we examined the relationship
between select demographic variables (age, gender, AAT experience, and having a pet …

Introduction: Biopharmaceuticals are large protein based drugs which are heterogeneous by
nature due to post translational modifications resulting from cellular production, processing …

… Spectra were recorded at 25C and 18.8 T on a Varian Unity INOVA spectrometer using a …
spectra were recorded at 25C and 18.8 T on a Varian Unity INOVA spectrometer using a …

… The DSC thermograms were found to be superimposable, with three partially overlapping
transitions with T m values of 71, 75 and 83 C for both GP2013 and originator product. The …

Hydrophilic-interaction liquid chromatography (HILIC), reversed-phase chromatography (RPC)
and porous graphitic carbon (PGC) chromatography are typically applied for liquid …

In contrast with conventional drugs, biopharmaceuticals are highly complex molecules with
remarkable heterogeneity. Protein glycosylation is an inherent source of this heterogeneity …

Hyperreactive sulfhydryl groups associated with the Ca 2+ release protein from sarcoplasmic
reticulum are shown to have a well defined reduction potential that is sensitive to the …

Control of neurotransmitter receptor expression and delivery to the postsynaptic membrane
is of critical importance for neural signal transduction at synapses. The γ-aminobutyric acid, …

… T cells and dendritic cells. It mediates several adhesive interactions between cells of the
immune system, eg dendritic cells and T cells, B cells and T cells, T … interfere with T cell homing, …