This study aimed to examine the effects of bile salts on pharmacokinetics of lovastatin,
which has low bioavailability. Lovastatin solid dispersions were prepared using sodium …

Pharmacokinetic parameters of oltipraz were compared after intravenous (10 mg/kg) and oral
(30 mg/kg) administration in rat model of diabetes mellitus induced by alloxan (rat model of …

Pharmacokinetics and therapeutic effects of oltipraz were evaluated after consecutive (once
per day at 30 mg/kg/day for 7 and 14 days) or intermittent (once per week at 100 mg/kg/…

Dose‐independent pharmacokinetics of oltipraz after intravenous and/or oral administration
at various doses to mice, rats, rabbits and dogs were evaluated. After both intravenous and/…

A series of in‐vitro and in‐vivo experiments, using various inducers and inhibitors of hepatic
microsomal cytochrome P450 (CYP) isozymes, was conducted to study oltipraz …

Abstract Effects of cysteine on the pharmacokinetics of oltipraz were investigated after iv (10
mg/kg) and oral (30 mg/kg) administration to male control, protein–calorie malnutrition (PCM)…

Pharmacokinetic parameters of oltipraz were compared after intravenous (10 mg/kg) and
oral (50 mg/kg) administration to control male Sprague–Dawely rats and mutant Nagase …

Purpose: The objective of the study was to examine the effect of lipoprotein-associated
cyclosporine on hepatic metabolism, hepatic lipoprotein receptors, and renal toxicity in …

Cyclosporine (CSA), in both humans and animals, is associated with plasma lipoproteins. It
has been demonstrated that CSA-lipoprotein association is partly responsible for the …

Based on the hypothesis that the therapeutic and toxic effects of cyclosporine (CSA) are
dependent on the in vivo disposition of lipoprotein-associated drug, we examined the metabolic …