Single particle optical sensing (SPOS) and visual inspection were used to characterize a
series of lipid injectable emulsions (n=21) featuring three lipid types, two electrolyte conditions, …

Objective: To evaluate the relationship between changes in emulsion globule size distributions
and container uptake of lipid emulsions in total nutrient admixtures. Methods: A total …

The physicochemical stability of an aqueous, phospholipid-based dispersion of itraconazole
microcrystals was studied as a model water-insoluble drug suspension. The particle size, …

OBJECTIVE: We evaluated the effects of glass and plastic containers on the physicochemical
properties of parenteral nutrition lipid emulsions and total nutrient admixtures with an …

Background: The information content of the calcium phosphate compatibility curves for adult
parenteral nutrition (PN) solutions may benefit from a more sophisticated statistical treatment…

OBJECTIVES Calcium and phosphate incompatibility in parenteral nutrition formulations
remains a critical concern for patient safety. This study examined calcium phosphate solubility …

The United States Pharmacopeia (USP) recently approved general information chapter 729,
which specifies limits for the lipid globule size distribution (GSD) of parenteral nutritional …

Detailing the kinetics of particle formation for pharmaceutically relevant solutions is
challenging, especially when considering the combination of formulations, containers, and …

“Lipid Injectable Emulsions: 2006.” 1 The article addresses 3 very important issues related
to lipid emulsions: clinical safety, characterization of lipid emulsions using globule size …

Pharmaceutical parenteral emulsions consisting of n-6 poly-unsaturated fatty acids (PUFAs)
alone (Intralipid®), n-6 PUFAs and n-9 mono-unsaturated fatty acids (MUFAs; eg Clinoleic®)…