New mechanistic insights regarding Pd/Cu catalysts for the Sonogashira reaction: HRMAS NMR studies of silica-immobilized systems

T Posset, J Blümel - Journal of the American Chemical Society, 2006 - ACS Publications
The title technique, high-resolution magic angle spinning NMR of suspensions, constitutes a
powerful new tool for investigating the structures and mobilities of immobilized species and, …

14N NMR and Two‐Dimensional Suspension 1H and 13C HRMAS NMR Spectroscopy of Ionic Liquids Immobilized on Silica

S Brenna, T Posset, J Furrer… - Chemistry–A European …, 2006 - Wiley Online Library
A variety of popular ionic liquids have been synthesized and characterized, including by
optimized 14 N NMR spectroscopy of the neat and dissolved ionic liquids. Ionic liquids …

Immobilized Sonogashira catalyst systems: new insights by multinuclear HRMAS NMR studies

T Posset, J Guenther, J Pope, T Oeser… - Chemical …, 2011 - pubs.rsc.org
A new chelate phosphine linker and its Pd and Cu complexes have been synthesized and
immobilized. The solvent impact on these immobilized species, their mobility, and …

New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC–MS and UPLC/QTOF-MS/MS analytics

N Scherer, K Marcseková, T Posset, G Winter - International Journal of …, 2019 - Elsevier
The increasing application of Single-Use Systems (SUSs) in pharmaceutical manufacturing
lines poses a potential risk of polymer-related impurities leaching into the process stream …

Electron attachment to clusters

T Sommerfeld, T Posset - The Journal of chemical physics, 2003 - pubs.aip.org
Vertical and adiabatic electron attachment to carbon dioxide clusters ( CO 2 ) N (N=2–5) is
studied at high ab initio levels of theory. As a first step the geometries of neutral and anionic …

Influence of different container closure systems and capping process parameters on product quality and container closure integrity (CCI) in GMP drug product …

…, J Huwyler, J Eder, K Fritsch, T Posset… - PDA journal of …, 2016 - journal.pda.org
Capping equipment used in good manufacturing practice manufacturing features different
designs and a variety of adjustable process parameters. The overall capping result is a …

Evaluation of stir-bar sorptive extraction coupled with thermal desorption GC–MS for the detection of leachables from polymer single use systems to drugs

N Scherer, K Marcseková, T Posset, G Winter - Journal of Pharmaceutical …, 2018 - Elsevier
Stir-bar Sorptive Extraction (SBSE) in combination with thermal desorption and gas
chromatography-mass spectrometry (TD-GC–MS) is widely accepted as the gold–standard analysis …

Critical Process Parameters of Capping Equipment Used in GMP DP Manufacturing

…, J Huwyler, J Eder, K Fritsch, T Posset… - PDA Journal of …, 2016 - journal.pda.org
Capping equipment used in good manufacturing practice (GMP) manufacturing feature different
designs and a variety of adjustable process parameters. The overall capping result is a …

[HTML][HTML] … Drug Powder in Crimped and Non-crimped Vials Feasibility study using TD-NMR spectroscopy Kristina Witt and Tobias Posset· Roche Diagnostics GmbH …

T Posset - ecv.de
It could be shown that the filling weight of solids for parenteral administration filled into 15R
vials can be determined by means of TD-NMR spectroscopy. For this purpose a Bruker …

Foreign particle characterisation of parenteral drug product solutions using scanning electron spectroscopy combined with energy dispersive x-ray spectroscopy

M Keller, K Lischka, T Posset - 2011 - publica.fraunhofer.de
This paper shows that it is possible to identify both extrinsic and intrinsic particles of organic,
inorganic and/or organometallic composition in parenteral drug solutions by means of SEM-…