Identification of antioxidants for prevention of peroxide-mediated oxidation of recombinant human ciliary neurotrophic factor and recombinant human nerve growth …

VM Knepp, JL Whatley, A Muchnik… - PDA journal of …, 1996 - journal.pda.org
Peroxides present in non-ionic surfactants used to stabilize certain recombinant protein
formulations (eg polysorbate 80) can result in the oxidative degradation of proteins. In this study, …

Controlled drug release from a novel liposomal delivery system. II. Transdermal delivery characteristics

VM Knepp, FC Szoka Jr, RH Guy - Journal of controlled release, 1990 - Elsevier
Recently, we reported the evaluation of a prototypal liposomal delivery system, which consisted
of a thin agarose gel throughout which a model drug progesterone (PG), associated with …

Controlled drug release from a novel liposomal delivery system. I. Investigation of transdermal potential

VM Knepp, RS Hinz, FC Szoka Jr, RH Guy - Journal of controlled release, 1987 - Elsevier
The in vitro release behavior of a novel liposome-based drug delivery device has been
characterized. The system consists of a molded agarose matrix in which the model drug (…

Stability of nonaqueous suspension formulations of plasma derived factor IX and recombinant human alpha interferon at elevated temperatures

VM Knepp, A Muchnik, S Oldmark… - Pharmaceutical …, 1998 - Springer
Purpose. To identify a suitable nonaqueous, parenterally acceptable suspending vehicle
whereby a therapeutic protein is delivered as a stable flowable powder, making it amenable to …

Transdermal drug delivery: problems and possibilities.

VM Knepp, J Hadgraft, RH Guy - Critical reviews in therapeutic drug …, 1987 - europepmc.org
Transdermal drug delivery has, in recent years, attracted considerable interest. However,
despite the obvious advantages of this novel route of drug administration to achieve systemic …

Quantitative Evaluation of the Stability and Delivery of lnterleukin-1 B by Infusion

…, MD Miller, T Calderwood, VM Knepp - PDA Journal of …, 1990 - journal.pda.org
The stability and delivery of IL-1β has been characterized in a polypropylene based syringe
pump infusion system and in polyvinyl chloride based infusion bags, at concentrations …

Transport of steroids at model biomembrane surfaces and across organic liquid-aqueous phase interfaces

VM Knepp, RH Guy - The Journal of Physical Chemistry, 1989 - ACS Publications
A simple technique for preparing mobile silver films at the interface between an aqueous
silver sol and solutions inorganic solvents of a variety of transition-metal complexes has been …

New liposomal delivery system for controlled drug release

VM Knepp, RS Hinz, FC Szoka Jr, RH Guy - 1987 - ACS Publications
The in vitro release characteristics of a liposomal drug delivery device have been studied.
The system consists of a molded agarose matrix in which progesterone is dispersed either …

[PDF][PDF] Controlled drug release from a novel liposomal delivery system

VM Knepp - 1989 - escholarship.org
… nitroglycerin (for a more in-depth discussion of nitrate tolerance, the reader is directed to
a review by Knepp et al., 1987 and references therein). … Generally these relationships …

Transport of steroids at model biomembrane surfaces and across organic liquid-aqueous phase interfaces [Erratum to document cited in CA111 (14): 120701m]

VM Knepp, RH Guy - Journal of Physical Chemistry, 1990 - ACS Publications
The fact that the rate of the chain reaction increases linearly with alcohol concentration (Figure
9) shows that reaction 19 is the rate-determining step of chain growth. Furthermore, as the …