Drug resistance is one of the critical reasons leading to failure in chemotherapy. Enormous
studies have been focused on increasing intracellular drug accumulation through inhibiting P-…

For designing a complex vector that has the advantages of both polyethylenimine (PEI) and
chitosan for gene delivery, a PEI/chitosan/DNA complex was constructed at various N/P …

In the present study we developed alginate–chitosan–poly(lactic-co-glycolic acid) (PLGA)
composite microspheres to elevate protein entrapment efficiency and decrease its burst …

This study aims to investigate the novel preparation of solid lipid nanoparticle-enriched
hydrogel (SLN-gel) for the topical delivery of astragaloside IV and to determine the effects of …

Most nonviral gene delivery systems are not efficient enough to manipulate the difficult-to-transfect
cell types, including non-dividing, primary, neuronal or stem cells, due to a lack of an …

PEI and chitosan are considered to be promising non-viral gene delivery vectors. To improve
the transfection efficiency of chitosan, we linked chitosan with polyethylenimine (PEI, Mw=…

Salidroside, the major active component of Rhodiola rosea, a herb with antioxidant, free radical
scavenging and tyrosinase inhibitory effects, has been recently reported in protecting the …

The combination of gene therapy and chemotherapy may increase the therapeutic efficacy
in the treatment of patients. In this work, the anti-cancer drug Dox and therapeutic gene …

The long‐term outcome of gastric cancer (GC) patients remains unsatisfactory despite some
recent improvements. Leukemia inhibitory factor (LIF) is a prognostic biomarker for some …

Self-assembly supramolecular nanoparticles (SNPs) are synthesized using polyethylenimine
(PEI) crosslinked by cyclodextrins (CyDs), adamantyl doxorubicin and plasmidDNA. SNPs …