The use of collagen as a biomaterial is currently undergoing a renaissance in the tissue
engineering field. The biotechnological applications focus on the aspects of cellular growth or …

Lyophilization is a common, but cost-intensive, drying process to achieve protein formulations
with long-term stability. In the past, typical process optimization has focused on the drying …

While entering a new century, lyophilization in the pharmaceutical field has been subjected
to ongoing development and steady expansion. This review aims to highlight recent …

Due to its biocompatibility and well-established safety profile, collagen represents a
favourable matrix for on-site drug delivery. In this review, we summarize some of the recent …

Protein aggregation is known to occur under different stress conditions and displays a wide
variety of morphologies. In this work, the aggregation behavior of a monoclonal antibody (…

The goal was to investigate the impact of NaCl on the physico-chemical properties of
mannitol–sucrose formulations during freezing and drying, with special focus on mannitol hydrate …

Control and analysis of protein aggregation is an increasing challenge to pharmaceutical
research and development. Due to the nature of protein interactions, protein aggregation may …

The presence of particles is a major issue during therapeutic protein formulation development.
Both proteinaceous and nonproteinaceous particles need to be analyzed not only due to …

Therapeutic protein candidates should exhibit favorable properties that render them suitable
to become drugs. Nevertheless, there are no well-established guidelines for the efficient …

Monoclonal antibody and Fc fusion protein drugs are complex heterogeneous mixtures of
numerous different protein variants and modifications. N-glycosylation as one of the most …