No Heading Purpose. The aim of this research was to develop a pH-dependent canine
absorption model for studying pH effect on both dissolution in vitro and pharmacokinetics in vivo …

This manuscript represents the perspective of the Dissolution Working Group of the International
Consortium for Innovation and Quality in Pharmaceutical Development (IQ) and of two …

In-situ dissolution testing using UV fiber optics has attracted much attention in the pharmaceutical
industry. Several instruments with different designs of fiber optic probes have been …

This publication summarizes the proceedings and key outcomes of the first day (“Day 1”) of
the 3-day workshop on “Dissolution and Translational Modeling Strategies Enabling Patient-…

Ultraviolet (UV) fiber optic spectroscopy has been applied to dissolution testing for more than
30 years. Multiple types of instrumentation schemes have been designed and implemented …

Assessing in vivo performance to inform formulation selection and development decisions is
an important aspect of drug development. Biopredictive dissolution methodologies for oral …

Impact of SDD-dissolution medium interactions on the swelling and dissolution of spray dried
dispersions (SDDs) was investigated using UV imaging by monitoring SDD swelling in situ, …

Transport within human tissue matrices, eg, the subcutaneous tissue, exhibits some
resemblance to chromatographic processes. Here, a porous matrix comprising agarose beads …

Cross-linking is a common problem in the dissolution of gelatin capsules. Cross-linking is
characterized by a bridge across the peptide backbone of the gelatin molecule which creates …

A UV imaging release-testing setup comprising an agarose gel as a model for tumorous tissue
was developed. The setup was optimized with respect to agarose concentration (0.5% (w/…