Background: US breast cancer incidence has been changing, as have distributions of risk
factors, including body mass index (BMI), age at menarche, age at first live birth, and number …

Background The A/H1N1/2009 influenza pandemic made evident the need for faster and
higher-yield methods for the production of influenza vaccines. Platforms based on virus culture …

We investigate a method to estimate the combined effect of multiple continuous/ordinal
mediators on a binary outcome: (a) fit a structural equation model with probit link for the outcome …

The demography, survival, and motor phenotypes of amyotrophic lateral sclerosis (ALS)
patients have been rarely described in Hispanic countries. The clinical characteristics and …

Although covariate measurement error is likely the norm rather than the exception, methods
for handling covariate measurement error in propensity score methods have not been widely …

Capping completes the closure of parenteral drug products in the final packaging container
and is critical in maintaining an integral seal to ensure product quality. Residual seal force (…

Big Data are of increasing importance in a variety of areas, especially in the biosciences.
There is an emerging critical need for Big Data tools and methods, because of the potential …

The BioPhorum Development Group Viral Clearance Workstream performed a collaborative
retrospective analysis to evaluate packed bed chromatographic resin performance after …

Although covariate measurement error is likely the norm rather than the exception, methods
for handling covariate measurement error in propensity score methods have not been widely …

Two statistically based testing procedures, a zero-failure test and a one-failure test, are
proposed for demonstrating that a vial capping process has an acceptably low rate of failed seals…